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    mProX™ Human LPAR3 Stable Cell Line

    [CAT#: S01YF-0923-PY99]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    LPAR3
    Target Family
    Lysophospholipid Family
    Target Protein Species
    Rat
    Host Cell Type
    WB-F344;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Cancer Research
    Related Diseases
    Trachea Adenoid Cystic Carcinoma;Tracheal Cancer
    Gene ID
    Rat: 66025
    UniProt ID
    Rat: Q8K5E0

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    LPAR3 has been associated with various cancer-related processes. Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) has been shown to enhance the cisplatin resistance of ovarian cancer. Additionally, LPAR3 has been identified as playing a role in promoting tumor progression in Ras-transformed cells through autophagy induction. In the context of esophageal cancer, circular RNA LPAR3 has been implicated in promoting cell migration, invasion, and metastasis. Furthermore, LPAR3 has been linked to the regulation of inflammation in human IL-1β-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats.

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    FAQ

    chat Elizabeth (Verified Customer)

    What is the role of the ATX-LPA signaling in breast cancer cell lines? Oct 31 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    ATX-LPA signaling has a dose-dependent stimulatory effect, especially on the cellular functions of triple-negative and luminal A breast cancer cell lines. This might contribute to identifying subtypes suitable for a future targeted therapy of the ATX-LPA axis. Oct 31 2022

    chat Elizabeth (Verified Customer)

    How does Circular RNA LPAR3 influence esophageal cancer? Jun 28 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Circular RNA LPAR3 can regulate the miR-198-MET signal axis to promote the migration, invasion, and metastasis of esophageal cancer cells. This suggests it could serve as a potential diagnostic and therapeutic target for esophageal cancer. Jun 28 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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