mProX™ Human KCNQ3 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
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Published Data
Fig.1 The KCNQ2 and KCNQ3 potassium channel subunits form heteromultimers.
Currents measured in Xenopus oocytes following the injection of KCNQ2 mRNA, KCNQ3 mRNA, or KCNQ2 and KCNQ3 mRNAs in an equimolar ratio. Currents drawn in 10-mV increments from a holding potential of 70 mV across the range of 60 to 0 mV using 2-s voltage steps.
Ref: Wang, Hong-Sheng, et al. "KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel." Science 282.5395 (1998): 1890-1893.
Pubmed: 9836639
DOI: 10.1126/science.282.5395.1890
Research Highlights
Patients with early onset epilepsies with wide phenotypic heterogeneity, from benign familial neonatal seizures (BFNS) to epileptic encephalopathy with cognitive impairment, drug resistance, and distinctive electroencephalography (EEG) and neuroradiologic features, have been found to have mutations in the KCNQ2 gene, which codes for voltage-gated potassium channel subunits.
Miceli, Francesco, et al. "A novel KCNQ3 mutation in familial epilepsy with focal seizures and intellectual disability." Epilepsia 56.2 (2015): e15-e20.
Pubmed:
25524373
DOI:
10.1111/epi.12887
The current study's findings indicate that KCNQ3 gene epigenetic modifications may play a role in the etiopathogenesis of BPD and emphasize the significance of accounting for medication and heterogeneity caused by cellular composition in psychiatric brain research.
Kaminsky, Zachary, et al. "DNA methylation and expression of KCNQ 3 in bipolar disorder." Bipolar disorders 17.2 (2015): 150-159.
