mProX™ Human KCNN4 Stable Cell Line

Product Information

Target Protein

KCNN4

Target Family

IKCa

Target Protein Species

Human

Host Cell Type

PDAC; CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

Cardiovascular Research; CNS Research

Related Diseases

Dehydrated Hereditary Stomatocytosis; Dehydrated Hereditary Stomatocytosis

Gene ID

3783

UniProt ID

O15554

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

One human gene that codes for the KCa3.1 protein is called potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4. Otherwise known as KCNN4. Intracellular calcium activates a voltage-independent potassium channel that may be heterotetrameric and contains the KCa3.1 protein. Membrane hyperpolarization occurs after activation and encourages calcium inflow. The encoded protein might be a component of T-lymphocytes' main calcium-activated potassium channel. Although this gene and other potassium channel genes in the KCNN family are similar, there are enough differences for it to potentially be placed in a distinct subfamily. The customized KCNN4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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I have always got fast and friendly response. Nov 30 2020

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mProX™ Human KCNN4 Stable Cell Line is very good! Feb 11 2021

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FAQ

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Published Data

Fig.1 The high expression of KCNN4 in PDAC is regulated by AP-1.

Based on the expression profile data from the clinical sample, the heatmap displayed the various expression patterns of 24 potassium channel genes in the PDAC tumor tissues (T) and matching normal tissues (MN).

Ref: Mo, Xiao, et al. "KCNN4-mediated Ca2+/MET/AKT axis is promising for targeted therapy of pancreatic ductal adenocarcinoma." Acta Pharmacologica Sinica 43.3 (2022): 735-746.

Pubmed: 34183755

DOI: 10.1038/s41401-021-00688-3

Research Highlights

Many different forms of cancer have been demonstrated to be encouraged to develop and progress by dysregulated potassium (K+) channels in the past. In the meantime, K+ channels play a crucial role in controlling the pancreatic exocrine and endocrine processes.
Jiang, Shuheng, et al. "Integrated expression profiling of potassium channels identifys KCNN4 as a prognostic biomarker of pancreatic cancer." Biochemical and biophysical research communications 494.1-2 (2017): 113-119.
Pubmed: 29050937 DOI: 10.1016/j.bbrc.2017.10.072

One of the most prevalent cancers in the world, hepatocellular carcinoma (HCC), is infamous for having a poor prognosis. A subclass of intermediate conductance calcium-activated potassium channels known as potassium calcium-activated channel subfamily N member 4 (KCNN4) may have a role in controlling invasion and metastasis in a variety of malignancies, according to mounting data.
Li, Qiu-Ting, et al. "KCNN4 promotes invasion and metastasis through the MAPK/ERK pathway in hepatocellular carcinoma." Journal of Investigative Medicine 68.1 (2020): 68-74.
Pubmed: 31431469 DOI: 10.1136/jim-2019-001073