KCNN4
In vertebrate neurons, action potentials are followed by an afterhyperpolarization (AHP) that may last for many seconds and may have significant effects on the neuron's firing pattern. Each AHP component has its own unique kinetics and is controlled by a unique calcium-activated potassium channel. This gene's protein contributes to the slow portion of synaptic AHP and is hypothesized to control neuronal excitability. The protein is activated prior to membrane hyperpolarization. Together with three other calmodulin-binding subunits, the encoded protein forms an integral membrane protein that functions as a voltage-independent calcium-activated channel. The potassium channel gene KCNN family includes this gene.
| Full Name | Potassium calcium-activated channel subfamily N member 4 |
| Gene ID | Human: 3783 Mouse: 16534 Rat: 65206 Monkey: 712383 |
| UniProt ID | Human: O15554 Mouse: O89109 Rat: Q9QYW1 Monkey: A0A1D5Q3T4 |
| Alternative Names | KCNN4; IK; IK1; SK4; DHS2; KCA4; hSK4; IKCA1; hKCa4; KCa3.1; hIKCa1; intermediate conductance calcium-activated potassium channel protein 4; SKCa 4; SKCa4; intermediate-conductance Ca2+-activated K+ channel, KCa3.1; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative Gardos channel; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; small conductance calcium-activated potassium channel 4; Potassium calcium-activated channel subfamily N member 4 |
Product List
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Magic™ Human KCNN4 HEK293 Cell Line
[CAT#: S01YF-0123-KX516]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KCNN4 Target Family: IKCa Target Protein Species: Human Protein Tag: FLAG-tag at N-terminal Host Cell Type: HEK293 Assay Types: Drug screening and biological assays
Magic™ mPro Human KCNN4 Cell Line
[CAT#: S01YF-1122-KX92]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KCNN4 Target Family: Calcium and Sodium Activated Potassium Channel Target Protein Species: Human
Magic™ mPro Human KCNN4 Cell Line with RFP-blasticidin
[CAT#: S01YF-1122-KX147]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KCNN4 Target Family: Calcium and Sodium Activated Potassium Channel Target Protein Species: Human
mProX™ Human KCNN4 Stable Cell Line
[CAT#: S01YF-1123-KX41]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: KCNN4 Target Family: IKCa Target Protein Species: Human Host Cell Type: PDAC; CHO-K1; HEK293
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