mProX™ Human KCNN3 Stable Cell Line

[CAT#: S01YF-1123-KX40]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: Ion Channel Cell Lines

Certificate of Analysis Lookup
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Lot Number

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Product Information

Target Protein

KCNN3

Target Family

SKCa

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

Cardiovascular Research; CNS Research

Related Diseases

Zimmermann-Laband Syndrome; Zimmermann-Laband Syndrome

Gene ID

3782

UniProt ID

Q9UGI6

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Activated by intracellular calcium, KCNN3 creates a voltage-independent potassium channel and is involved in numerous physiological functions. It has been observed that KCNN3 plays a role in the initiation and advancement of several solid tumors. By hyperpolarizing the potential of the cell membrane, KCNN3 overexpression in melanoma cells improves the pathways involved in cell motility. In breast cancer cells, KCNN3 mediates both cell migration and invasiveness that is dependent on cysteine cathepsin. Via the arterial smooth muscle membrane potential, the endothelium's expression of KCNN3 channels affects arterial tone. Serious neurological conditions such as schizophrenia, bipolar disorder, Alzheimer's disease, anorexia nervosa, ataxia, and myotonic muscular dystrophy are consistently associated with mutations in KCNN3. The customized KCNN3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Jennifer

Cost and time-savings, while bringing our product to the market. Jan 01 2020

chat Verified Customer

chat Kimberly

Very easy to use for drug screening and fast turnaround. Oct 13 2022

chat Verified Customer

FAQ

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