mProX™ Human KCNMA1 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
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Published Data
Fig.1 Location and consequence of KCNMA1 variants in the BK K+ channel.
Sample inside-out patch-clamp recordings from HEK293 cells expressing the BKWT, BKN999S, BKD434G, and BKH444Q channels. In symmetrical K+ and 1 μM intracellular Ca2+, macroscopic BK currents were measured by maintaining patches at -100 mV, stepping from -100 to 250 mV for 30 ms, and then performing a tail step of -100 mV for 15 ms.
Ref: Park, Su Mi, et al. "BK channel properties correlate with neurobehavioral severity in three KCNMA1-linked channelopathy mouse models." Elife 11 (2022): e77953.
Pubmed: 35819138
DOI: 10.7554/eLife.77953
Research Highlights
Movement problem, seizures, intellectual disability, and developmental delay can occur in different and overlapping combinations in KCNMA1-linked channelopathy, a newly diagnosed neurological condition.
Miller, Jacob P., et al. "An emerging spectrum of variants and clinical features in KCNMA1-linked channelopathy." Channels 15.1 (2021): 447-464.
Pubmed:
34224328
DOI:
10.1080/19336950.2021.1938852
The large-conductance Ca2+-activated K⁺ channel's pore-forming α-subunit is encoded by the KCNMA1 gene, which is located at 10q22. Gastric carcinoma tumors exhibit down-regulation of KCNMA1 due to hypermethylation of its promoter.
Basile, Maria Sofia, et al. "KCNMA1 expression is downregulated in colorectal cancer via epigenetic mechanisms." Cancers 11.2 (2019): 245.
Pubmed:
30791468
DOI:
10.3390/cancers11020245
