mProX™ Human KCNJ4 Stable Cell Line

Product Information

Target Protein

KCNJ4

Target Family

GIRK

Target Protein Species

Human

Host Cell Type

Calu-3; A549; NCI-H209; NCI-H460; CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

Cardiovascular Research; CNS Research

Related Diseases

Andersen Cardiodysrhythmic Periodic Paralysis; Epilepsy

Gene ID

3761

UniProt ID

P48050

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

KCNJ4, sometimes referred to as Kir2.3 or potassium inwardly-rectifying channel, subfamily J, member 4, is a gene found in humans. The nervous system's electrical signaling is known to be mediated by a number of distinct potassium channels. This imbalance in the conductance of potassium ions is crucial for the excitability of neurons and muscle cells. This gene codes for an integral membrane protein that belongs to the family of potassium channels found in inward rectifiers. In comparison to other proteins in this family, the encoded protein has a low unitary conductance. For this gene, two transcript variants that encode the same protein have been discovered. The customized KCNJ4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Kimberly

A great customized cell line. Nov 04 2021

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chat Donna

The Human KCNJ4 Stable Cell Line worked well! Sep 12 2021

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FAQ

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Published Data

Fig.1 Correlations between miR-34c-5p and POU6F2-AS1 or KCNJ4.

Based on the TCGA database and the GEO dataset, the relative expression level of miR-34c-5p in LADC tissues and normal tissues. Using Pearson's correlation analysis, the association between miR-34c-5p, also known as POU6F2-AS1, and KCNJ4 was found.

Ref: Wu, Xiao-Yan, et al. "Long noncoding RNA POU6F2-AS1 regulates lung cancer aggressiveness through sponging miR-34c-5p to modulate KCNJ4 expression." Genetics and molecular biology 44 (2021).

Pubmed: 33999092

DOI: 10.1590/1678-4685-GMB-2020-0050

Research Highlights

Novel anticancer drugs inhibit the inward rectifier potassium channel family, which includes KCNJ4. Nevertheless, little is known about the biologic importance of KCNJ4 in lung adenocarcinoma (LADC).
Wu, Xiao-Yan, and Xue-Yan Yu. "Overexpression of KCNJ4 correlates with cancer progression and unfavorable prognosis in lung adenocarcinoma." Journal of Biochemical and Molecular Toxicology 33.4 (2019): e22270.
Pubmed: 30512237 DOI: 10.1002/jbt.22270

The potassium channel protein-coding KCNJ4 gene has been suggested as a cellular genetic marker for viral PV detection.
Sano, D., et al. "Selection of cellular genetic markers for the detection of infectious poliovirus." Journal of applied microbiology 124.4 (2018): 1001-1007.
Pubmed: 29078036 DOI: 10.1111/jam.13621