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  • mProX™ Human KCNC2 Stable Cell Line

    [CAT#: S01YF-1123-KX25]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    KCNC2
    Target Family
    Kv3
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    Cardiovascular Research; CNS Research
    Related Diseases
    Extratemporal Epilepsy; Spinocerebellar Ataxia
    Gene ID
    UniProt ID

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Fast-spiking GABAergic interneurons in the cortical and hippocampus regions of the brain are where Kv3.2 proteins are primarily expressed. Excitation/inhibition (E/I) balance in the central nervous system must be maintained by sustained high-frequency firing of GABAergic interneurons. A frequent neuropathological hallmark of many developmental diseases, including Rett syndrome, and epilepsy, is the lack of E/I balance. In the neurons of seizure-sensitive gerbils, for instance, Kv3.2 immunoreactivity is substantially lower than it is in the neurons of seizure-resistant gerbils. In particular, KCNC2-knockout mice exhibit aberrant EEG patterns, poor cortical inhibition, and increased susceptibility to epileptic seizures. However, there isn't enough concrete data to prove that Kv3.2 channels play a part in human encephalopathy. The customized KCNC2 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

    Protocols

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    Customer Reviews

    chat Shirley

    I recomended KCNC2 Knock out cell line to my lab members. The delivery is much faster than I expected. Jun 22 2020

    chat Verified Customer

    chat Joseph

    The KCNC2 cell lines definitely stand out. They are an excellent investment because of their unparalleled performance and quality. Oct 22 2021

    chat Verified Customer

    FAQ

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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