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    Family stable cell lines 5-Hydroxytryptamine Family Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human HTR2A Stable Cell Line

    [CAT#: S01YF-0923-KX34]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX916 Magic™ Rabbit HTR2A in Vitro IP1 Assay Rabbit CHO-K1 IP1 Assay
    S01YF-1122-KX917 Magic™ Rabbit HTR2A in Vitro Radioligand Binding Assay Rabbit CHO-K1 Radioligand Binding Assay
    S01YF-1122-KX918 Magic™ Rat HTR2A in Vitro Calcium Flux Assay Rat CHO-K1-Gα16 Calcium Flux Assay
    S01YF-1122-KX919 Magic™ Rat HTR2A in Vitro IP1 Assay Rat CHO-K1 IP1 Assay
    S01YF-1122-KX920 Magic™ Rat HTR2A in Vitro Radioligand Binding Assay Rat CHO-K1 Radioligand Binding Assay

    Product Information

    Target Protein
    HTR2A
    Target Family
    5-Hydroxytryptamine Family
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research; Cardiovascular Research; Digestive and Renal Research
    Related Diseases
    Major Depressive Disorder; Obsessive-Compulsive Disorder
    Gene ID
    3356
    UniProt ID
    P28223

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The neurotransmitter serotonin has a receptor in the body called HTR2A. It promotes the activation of alternative signaling pathways while suppressing G protein-mediated signaling. The central nervous system's 5-HT2A is activated, which raises body temperature and boosts ACTH release. 5-HT2A mediates the contractile reactions of vascular smooth muscle, as well as a part of the gastrointestinal smooth muscle, to 5-HT in the periphery. Additionally, it might contribute to arterial vasoconstriction. Phospholipase C is activated by 5-HT2A signaling, as is a second messenger pathway involving phosphatidylinositol and calcium that controls the activity of phosphatidylinositol 3-kinase and facilitates the release of Ca2+ ions from intracellular storage. It also affects neuronal activity, perception, cognition, and emotion, making it a potential drug and psychoactive substance receptor. The customized HTR2A stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human HTR2A Stable Cell Line (S01YF-0923-KX34). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Rae (Verified Customer)

    What does the report look like? Feb 17 2023

    chat Sherry Smith (Creative Biolabs Scientific Support)

    The report consists of a description of the method, the QC of flow cytometry to verify the surface expression at the protein level, and qPCR to verify the engineering results at the mRNA level. Feb 17 2023

    chat Natalie (Verified Customer)

    Which selection marker should I use? Jun 09 2023

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Creative Biolabs offers a variety of selection markers, such as puromycin (Puro), neomycin (Neo), hygromycin B (Hygro) and blasticidin (Bsd). Jun 09 2023

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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