mProX™ Human HCN4 Stable Cell Line
[CAT#: S01YF-1123-KX87]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
HCN4
Target Family
Hyperpolarization-activated, Cyclic Nucleotide-gated Channels
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
Ion Channel Cell Lines
Target Research Area
Cardiovascular Research; CNS Research
Related Diseases
Sick Sinus Syndrome; Brugada Syndrome
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The hyperpolarization-activated funny current necessary for sinoatrial node automaticity is mediated by the HCN4 channels. This is demonstrated in transgenic mice that had the HCN4 gene specifically knocked out in the heart, resulting in severe progressive bradycardia. These channels are strongly expressed in the sinus node, and it has also been discovered that familial SND is linked to mutations in the HCN4 gene. These loss-of-function mutations cause a decrease in the diastolic depolarization range of sinoatrial cells, which can lead to a variety of abnormalities and decreased impulse generation. More variations with sinus bradycardia, chronotropic incompetence, and atrial fibrillation have been found in various families. The customized HCN4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Jennifer
I recently had the opportunity to try the HCN4 cell line from Creative Biolabs, and I am quite impressed. The product arrived promptly, and the packaging was secure. The provided instructions were clear and easy to follow.
Apr 22 2020
Verified Customer
Jessica
I can't speak highly enough about the HCN4 cell line. It has exceeded my expectations in terms of performance and has become an invaluable asset in our lab.
Sep 06 2023
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
