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    mProX™ Human HCAR2 Stable Cell Line

    [CAT#: S01YF-0923-PY148]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
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    Product Information

    Target Protein
    HCAR2
    Target Family
    Nicotinic Acid Family
    Target Protein Species
    Human
    Host Cell Type
    AG09429;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Digestive and Renal Research;Metabolic Research
    Related Diseases
    Pellagra;Diversion Colitis
    Gene ID
    Human: 338442
    UniProt ID
    Human: Q8TDS4

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    HCAR2, also known as GPR109A, is a receptor that has been identified as a target for the anti-inflammatory effects of beta-hydroxybutyrate, the principal ketone body produced during ketogenesis. This receptor has been implicated in the anti-inflammatory actions of nicotinic acid and beta-hydroxybutyrate in macrophages and dendritic cells, which are crucial immune cells involved in inflammation and immune responses. Activation of HCAR2 can lead to the suppression of inflammatory responses, suggesting its potential therapeutic role in inflammatory diseases. The receptor's role in mediating the anti-lipolytic effects of nicotinic acid in adipocytes further underscores its significance in metabolic processes.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human HCAR2 Stable Cell Line (S01YF-0923-PY148). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Donna (Verified Customer)

    How does HCAR2 contribute to membrane protein cell line development? Jun 16 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    HCAR2, like other membrane proteins, can benefit from the Tag-on-Demand approach, which utilizes amber codon suppression technology for cell line development. Jun 16 2023

    chat Christopher (Verified Customer)

    How does HCAR2 compare with other membrane proteins in cell line research? Jan 18 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    HCAR2, similar to other membrane proteins, can be incorporated into diverse cell line development strategies, including those that leverage advanced methods like amber codon suppression technology. Jan 18 2021

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    • mProX™ Human HCAR2 Stable Cell Line (CAT#: S01YF-0923-PY148)
    • Magic™ Human HCAR2 U2OS Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay (CAT#: S01YF-1222-KX95)
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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