HCAR2
Activates as a high affinity receptor for nicotinic acid and (D)-beta-hydroxybutyrate, and through G(i)-protein-mediated regulation of adenylyl cyclase, regulates increased adiponectin secretion and decreased lipolysis. Nicotinic acid levels that are far higher than those delivered by a typical diet are necessary for this pharmacological effect. mediates the apoptosis that nicotinic acid causes in mature neutrophils. When nicotinic acid activates a receptor, cAMP levels are decreased. This can have an impact on the activity of cAMP-dependent protein kinase A and the phosphorylation of target proteins, which can cause neutrophil apoptosis.
Full Name | Hydroxycarboxylic acid receptor 2 |
Gene ID | Human: 338442 Mouse: 80885 Rat: 353250 Monkey: 104666306 |
UniProt ID | Human: Q8TDS4 Mouse: Q9EP66 Rat: Q80Z39 Monkey: A0A7N9CM43 |
Alternative Names | HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A; G protein-coupled receptor HM74a; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; hydroxy-carboxylic acid receptor 2; niacin receptor 1; nicotinic acid receptor; HCAR2; Hydroxycarboxylic acid receptor 2 |
Product List
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Nicotinic Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Hydroxycarboxylic acid Receptors Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Hydroxycarboxylic acid Receptors Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Binding and Functional Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Hydroxycarboxylic acid Receptors Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Nicotinic Acid Family Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: β-arrestin assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Nicotinic Acid Family Target Protein Species: Human Host Cell Type: AG09429;CHO-K1;HEK293