HCAR2
Activates as a high affinity receptor for nicotinic acid and (D)-beta-hydroxybutyrate, and through G(i)-protein-mediated regulation of adenylyl cyclase, regulates increased adiponectin secretion and decreased lipolysis. Nicotinic acid levels that are far higher than those delivered by a typical diet are necessary for this pharmacological effect. mediates the apoptosis that nicotinic acid causes in mature neutrophils. When nicotinic acid activates a receptor, cAMP levels are decreased. This can have an impact on the activity of cAMP-dependent protein kinase A and the phosphorylation of target proteins, which can cause neutrophil apoptosis.
| Full Name | Hydroxycarboxylic acid receptor 2 |
| Gene ID | Human: 338442 Mouse: 80885 Rat: 353250 Monkey: 104666306 |
| UniProt ID | Human: Q8TDS4 Mouse: Q9EP66 Rat: Q80Z39 Monkey: A0A7N9CM43 |
| Alternative Names | HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A; G protein-coupled receptor HM74a; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; hydroxy-carboxylic acid receptor 2; niacin receptor 1; nicotinic acid receptor; HCAR2; Hydroxycarboxylic acid receptor 2 |
Product List
Loading...
Magic™ Human FLAG tagged HCAR2 CHO-K1 Cell Line, Calcium flux assay
[CAT#: S01YF-1022-KX488]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Nicotinic Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
Magic™ Human HCAR2 CHO-K1 Cell Line with Aequorin Reporter, Calcium flux assay
[CAT#: S01YF-1222-KX218]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Hydroxycarboxylic acid Receptors Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
Magic™ Human HCAR2 CHO-K1 Cell Line, Binding and Functional Assay
[CAT#: S01YF-1222-KX219]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Hydroxycarboxylic acid Receptors Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Binding and Functional Assay
Magic™ Human HCAR2 U2OS Cell Line with BLA (Beta-Lactamase) Reporter, Reporter Assay
[CAT#: S01YF-1222-KX95]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Hydroxycarboxylic acid Receptors Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
mProX™ Human HCAR2 Stable Cell Line
[CAT#: S01YF-0923-PY148]
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: HCAR2 Target Family: Nicotinic Acid Family Target Protein Species: Human Host Cell Type: AG09429;CHO-K1;HEK293
Can't find the products you're looking for? Optimize our parameters for better results.
Filter By Tag
Note: All of our products are for Research Use Only (RUO). NOT intended for diagnostic, therapeutic or clinical use. We DO NOT offer patients any direct products or services. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
