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HCAR2

Activates as a high affinity receptor for nicotinic acid and (D)-beta-hydroxybutyrate, and through G(i)-protein-mediated regulation of adenylyl cyclase, regulates increased adiponectin secretion and decreased lipolysis. Nicotinic acid levels that are far higher than those delivered by a typical diet are necessary for this pharmacological effect. mediates the apoptosis that nicotinic acid causes in mature neutrophils. When nicotinic acid activates a receptor, cAMP levels are decreased. This can have an impact on the activity of cAMP-dependent protein kinase A and the phosphorylation of target proteins, which can cause neutrophil apoptosis.

Full Name Hydroxycarboxylic acid receptor 2
Gene ID Human: 338442
Mouse: 80885
Rat: 353250
Monkey: 104666306
UniProt ID Human: Q8TDS4
Mouse: Q9EP66
Rat: Q80Z39
Monkey: A0A7N9CM43
Alternative Names HCA2; HM74a; HM74b; PUMAG; NIACR1; Puma-g; GPR109A; G protein-coupled receptor HM74a; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; hydroxy-carboxylic acid receptor 2; niacin receptor 1; nicotinic acid receptor; HCAR2; Hydroxycarboxylic acid receptor 2

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Product Category:
Membrane Protein Stable Cell Lines
Target Protein: HCAR2 Target Family: Nicotinic Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
Product Category:
Membrane Protein Stable Cell Lines
Target Protein: HCAR2 Target Family: Hydroxycarboxylic acid Receptors Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Calcium flux assay
Product Category:
Membrane Protein Stable Cell Lines
Target Protein: HCAR2 Target Family: Hydroxycarboxylic acid Receptors Target Protein Species: Human Host Cell Type: CHO-K1 Assay Types: Binding and Functional Assay
Product Category:
Membrane Protein Stable Cell Lines
Target Protein: HCAR2 Target Family: Hydroxycarboxylic acid Receptors Target Protein Species: Human Host Cell Type: U2OS Assay Types: Reporter Assay
Product Category:
Membrane Protein Stable Cell Lines
Target Protein: HCAR2 Target Family: Nicotinic Acid Family Target Protein Species: Human Protein Tag: TEV protease Host Cell Type: U2OS Assay Types: β-arrestin assay
Product Category:
Membrane Protein Stable Cell Lines
Target Protein: HCAR2 Target Family: Nicotinic Acid Family Target Protein Species: Human Host Cell Type: AG09429;CHO-K1;HEK293
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