mProX™ Human GRPR Stable Cell Line

Product Information

Target Protein

GRPR

Target Family

Bombesin Family

Target Protein Species

Human

Host Cell Type

A549;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research

Related Diseases

Agoraphobia;Gastrinoma

Gene ID

Human: 2925

UniProt ID

Human: P30550

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The Gastrin-Releasing Peptide Receptor (GRPR) has emerged as a significant target in scientific research, particularly in the realm of oncology. GRPR's role in prostate cancer has been highlighted in studies such as the synthesis and evaluation of radio-iodinated GRPR/PSMA bispecific heterodimers, which are seen as promising agents for theranostics applications in prostate cancer. Additionally, the development of GRPR-targeting radiopharmaceuticals, especially for targeted radioligand therapy application, has been underscored due to the low pancreas uptake of its derivatives. Furthermore, the potential of GRPR in the surgical removal of GRPR-positive tumors has been demonstrated through the development of dual-modality probes for nuclear and fluorescence imaging. Clinical studies of radioactive GRP analogues suggest promising opportunities for both diagnostic tumor imaging and radiotherapy of GRPR-expressing cancers. In essence, the application of GRPR in scientific research is vast, with its potential in diagnostics, therapeutics, and surgical interventions being actively explored.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Anthony (Verified Customer)

Is GRPR expression limited to the spinal cord? May 08 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

No, GRPR is expressed in various tissues and plays diverse roles, including in the progression of prostate cancer and other urological cancers. May 08 2023

chat Linda (Verified Customer)

Are there standardized criteria for interpreting GRPR-targeted PET? Apr 21 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Yes, modified PROMISE criteria have been proposed to aid clinicians in evaluating, reporting, and comparing GRPR-targeted PET. Apr 21 2020

Published Data

Fig.1 Effect of GPPr knockdown on the imaging of A549 cells.

Both standard A549 cells and A549 cells with depleted GRPr were exposed to complex 8 (10 µM) for a duration of 2 hours. Cellular imagery was captured at λ_excemi = 405/570−690 nm, and a scale bar of 25 μm was employed for reference.

Ref: Wang, Wanhe, et al. "Peptide-Conjugated Long-Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells." Angewandte Chemie 132.41 (2020): 18053-18058.

Pubmed: 32649787

DOI: 10.1002/anie.202007920