mProX™ Human GRM8 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Evaluation GRM8 effects on breast cancer cell apoptosis.
Among the breast cell lines discussed, SK-BR-3 exhibited the most pronounced GRM8 expression. To inhibit GRM8 levels in SK-BR-3 cells, we introduced sh-GRM8, resulting in a substantial increase in apoptosis within these cells. (*P<0.05)
Ref: Zhang, Chunxu, et al. "Metabotropic glutamate receptor 8 is regulated by miR-33a-5p and functions as an oncogene in breast cancer." Journal of Oncology 2021 (2021).
Pubmed: 34950209
DOI: 10.1155/2021/8002087
Research Highlights
Nievergelt CM, et al. "Discovery of 95 PTSD loci provides insight into genetic architecture and ." medRxiv : the preprint server for health sciences, 2023.
Posttraumatic stress disorder (PTSD) genetics are often less discoverable compared to other psychiatric disorders. Previous studies have been limited in providing a biological understanding of PTSD. A multi-ancestry meta-analysis was conducted on genome-wide association studies including over 1.2 million individuals of European ancestry (137,136 cases) and 58,051 individuals with African and Native American ancestry (13,624 cases). This study identified 95 significant genetic locations, with 80 of them being newly discovered. Further analysis using multi-omic approaches revealed 43 potential causal genes, such as neurotransmitter and ion channel synaptic modulators, developmental and transcription factors, and endocrine or immune regulators. These findings enhance our knowledge of the neurobiological systems relevant to PTSD and suggest new avenues for future research.
Pubmed:
37693460
DOI:
10.1101/2023.08.31.23294915
Liu J, et al. "A pilot study on glutamate receptor and carrier gene variants and risk of ." Metabolic brain disease, 2023.
The genotypes and allele distributions of various SNPs were examined for potential associations with the risk and severity of autism spectrum disorder (ASD) in the Chinese Han population. The results showed that the rs1800656 and rs2237731 SNPs in the GRM8 gene were significantly related to the severity of language impairment in children with ASD. However, no other SNPs were found to be associated with the risk of ASD or overall severity of the disorder. These findings provide support for the involvement of the SLC25A12 gene variant in the risk of childhood ASD and the GRM8 gene variant in the severity of language impairment.
Pubmed:
37578654
DOI:
10.1007/s11011-023-01272-w
