mProX™ Human GRIN1/GRIN2C Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
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Published Data
Fig.1 Effects of GRIN1 deletion on proliferation and differentiation of Meg-01 cells.
Meg-01 and Meg-01-GRIN1 À/À cell representative pictures captured with Hoffman modulation contrast microscopy. The majority of unaltered Meg-01 cells grew singly in suspension. Meg-01-GRIN1 À/À cells, in contrast, were bigger, more granular, and more adherent.
Ref: Hearn, James I., et al. "N-methyl-d-aspartate receptor hypofunction in meg-01 cells reveals a role for intracellular calcium homeostasis in balancing megakaryocytic-erythroid differentiation." Thrombosis and Haemostasis 120.04 (2020): 671-686.
Pubmed: 32289863
DOI: 10.1055/s-0040-1708483
Research Highlights
The modulation of glutamate transmission through N-methyl-D-aspartate receptors (NMDARs) has been proposed as a potential etiological mechanism in schizophrenia (SCZ) and autism spectrum disorder (ASD).
Yu, Yanjie, et al. "Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility." Translational psychiatry 8.1 (2018): 12.
Pubmed:
29317596
DOI:
10.1038/s41398-017-0061-y
