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  3. mProX™ Human GRIN1/GRIN2B Stable Cell Line
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    Family stable cell lines Glutamate Receptor Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human GRIN1/GRIN2B Stable Cell Line

    [CAT#: S01YF-1123-KX71]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Host Cell Type:
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    Product Information

    Target Protein
    GRIN1/GRIN2B
    Target Family
    Glutamate Receptor
    Target Protein Species
    Human
    Host Cell Type
    COS-7; CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Neurodevelopmental Disorder
    Gene ID
    2902
    UniProt ID
    Q05586

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The NMDA receptor subunit NR2B is encoded by GRIN2B. De novo mutations in this gene have been linked to Lennox-Gastaut syndrome, infantile spasms, West syndrome, and intellectual disability with focal epilepsy. It's interesting to note that GRIN2B mutations appear to have very distinct functional effects than GRIN2A mutations. Three glutamatergic signaling genes have been shown to have genetic variations or different expression patterns, which are linked to the severity of AWS in humans. Alcoholics who have a functional Ser310Ala polymorphism in the GRIK3 gene have delirium tremens. GRIN1 genotypes containing A and the 2108A allele were linked to a history of withdrawal-induced seizures. The GRIN2B gene, which codes for the NR2B subunit of the NMDA receptor, has polymorphisms that have not been linked to alcoholism, seizures brought on by alcohol withdrawal, or delirium tremens. The customized GRIN1/GRIN2B stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human GRIN1/GRIN2B Stable Cell Line (S01YF-1123-KX71). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Patricia (Verified Customer)

    Can the GRIN1/GRIN2B cell line be used in PPI studies? Jul 11 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Yes, cell lines expressing specific proteins can be used in PPI studies. Jul 11 2020

    chat James (Verified Customer)

    Does the GRIN1/GRIN2B stable cell line overexpress the full-length GRIN1/GRIN2B? May 19 2021

    chat Sherry Smith (Creative Biolabs Scientific Support)

    Yes, the GRIN1/GRIN2B stable cell line can be customized to overexpress the full-length GRIN1/GRIN2B. May 19 2021

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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