mProX™ Human GPR6 Stable Cell Line

[CAT#: S01YF-0923-PY156]

Product Category:: Membrane Protein Stable Cell Lines

Subcategory:: GPCR Cell Lines

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Lot Number

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Product Information

Target Protein

GPR6

Target Family

Orphan Family

Target Protein Species

Mouse

Host Cell Type

MGN3-1;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research

Related Diseases

Lennox-Gastaut Syndrome

Gene ID

Mouse: 140741

UniProt ID

Mouse: Q6YNI2

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

GPR6 is an orphan receptor that has been associated with various physiological functions. Recent studies have shown that GPR6 plays a role in Parkinson's disease, with CVN424, a potent GPR6 inverse agonist, demonstrating effectiveness in preclinical models of the disease. The discovery of CVN424 has opened new avenues for therapeutic interventions targeting GPR6 in neurodegenerative disorders.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Karen (Verified Customer)

What role does GPR6 play in inflammation? Jul 13 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

GPR6 is an orphan receptor that has been suggested to modulate inflammation, especially in the presence of an inflammatory environment in adipocytes. Targeting GPR6 could be a therapeutic strategy to reduce inflammation in diseases related to low-grade inflammation. Jul 13 2022

chat Christopher (Verified Customer)

How is GPR6 associated with Parkinson's Disease? Jun 04 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

GPR6 has been identified as a potential therapeutic target for Parkinson's Disease. Inhibition of GPR6 activity in vivo has been shown to normalize activity in basal ganglia circuitry and improve motor behavior. CVN424, a GPR6 inverse agonist, has demonstrated efficacy in preclinical models of Parkinson's Disease. Jun 04 2020

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