mProX™ Human GPR26 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 GPR26 protected against the production of free radical oxygen species.
In investigating the influence of GPR26 on ROS generation triggered by HG, researchers carried out GPR26 depletion in THP-1 cells exposed to NG or HG for various time intervals (24, 48, and 72 h). Their findings affirmed that HG significantly elevated ROS levels in HG-induced THP-1 cells over the full 72-hour period when compared to NG. Intriguingly, the suppression of GPR26 intensified ROS generation in a progressive temporal pattern, thereby amplifying HG-induced ROS production.
Ref: Kichi, Zahra Abedi, et al. "Orphan GPR26 Counteracts Early Phases of Hyperglycemia-Mediated Monocyte Activation and Is Suppressed in Diabetic Patients." Biomedicines 10.7 (2022): 1736.
Pubmed: 35885041
DOI: 10.3390/biomedicines10071736
Research Highlights
Gutierrez-Rojas RA, et al. "Glycine Effect on the Expression Profile of Orphan Receptors GPR21, GPR26, GPR39, ." Life (Basel, Switzerland), 2022.
The authors conducted a study to investigate the role of orphan receptors GPR21, GPR39, GPR82, and GPR6 in a chronic inflammatory process in 3T3-L1 cells. Adipocytes were stimulated with TNF-alpha as an inflammatory model, and gene expression was measured using RT-qPCR. Results showed a decrease in the expression of GPR21, GPR26, GPR39, GPR82, and GPR6 in response to the inflammatory stimulus. These findings suggest that glycine may modulate GPR21 and GPR82, potentially providing a therapeutic target for conditions associated with chronic inflammation, such as diabetes, obesity, and metabolic syndrome.
Pubmed:
36362842
DOI:
10.3390/life12111687
Weible AP, et al. "A genetically identified population of layer 4 neurons in auditory cortex that ." Frontiers in neural circuits, 2022.
The detection of sound events is a crucial task for the auditory system, which relies on spiking in cortical neurons to achieve this. However, the specific roles of certain cell types and circuits in this process are not fully understood. To address this, a genetically identified population of layer 4 auditory cortical neurons was examined for their involvement in sound detection. Using a Gpr26-Cre driver line, which is predominantly found in layer 4, the researchers measured sound detection using a common variant of pre-pulse inhibition. It was found that photostimulation of these cells, which respond to gaps in noise, was able to reduce the startle reflex. Additionally, photosuppression of these cells resulted in decreased neural responses to gaps and impaired behavioral gap detection. These findings suggest that cortical Gpr26 neurons play a crucial role in top-down modulation of the acoustic startle reflex and are likely involved in sound detection.
Pubmed:
36160948
DOI:
10.3389/fncir.2022.972157
