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    mProX™ Human GPR183 Stable Cell Line

    [CAT#: S01YF-0923-PY160]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
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    Product Information

    Target Protein
    GPR183
    Target Family
    Orphan Family
    Target Protein Species
    Mouse
    Host Cell Type
    RAW264.7;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Metabolic Research
    Related Diseases
    Bile Acid Synthesis Defect, Congenital, 3;Congenital Bile Acid Synthesis Defect
    Gene ID
    Mouse: 321019
    UniProt ID
    Mouse: Q3U6B2

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR183 has been identified as playing a pivotal role in immune responses, especially in the context of infections. For instance, eosinophils, which are among the first cells to respond to Mycobacterium tuberculosis infection, are rapidly recruited to the lung via GPR183-mediated mechanisms. Additionally, in the context of severe viral respiratory infections like influenza and SARS-CoV-2, GPR183 has been shown to drive inflammation in the lung.

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    FAQ

    chat Emily (Verified Customer)

    What is the function of GPR183? Sep 14 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR183, also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), is expressed in lymphocytes and acts as a chemotactic receptor for various immune cells. It's known to mediate cell positioning and movement in response to oxysterol ligands like 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC)​​. Sep 14 2022

    chat Elizabeth (Verified Customer)

    What is the relevance of GPR183 in diabetes research? May 21 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Research has shown GPR183 to be differentially expressed in diabetic/hyperglycemic human islets, and its silencing was found to impair insulin secretion, indicating a potential role in glucose metabolism and insulin regulation​. May 21 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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