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    mProX™ Human GPR161 Stable Cell Line

    [CAT#: S01YF-0923-PY175]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    GPR161
    Target Family
    Orphan Family
    Target Protein Species
    Human
    Host Cell Type
    MCF-10A;MDA-MB-361;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research;Metabolic Research
    Related Diseases
    Medulloblastoma;Pituitary Stalk Interruption Syndrome
    Gene ID
    Human: 23432
    UniProt ID
    Human: Q8N6U8

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    GPR161 has been identified as a significant player in the Hedgehog signaling pathway, a critical pathway involved in embryonic development and tissue regeneration. Specifically, GPR161's role in regulating cAMP signaling within the primary cilium is crucial for maintaining the off state of Hedgehog signaling. Moreover, GPR161's involvement in the regulation of the Hedgehog pathway has implications in various developmental processes and diseases, including cancer5. The ongoing exploration of GPR161's function provides valuable insights into its potential therapeutic applications.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Robert (Verified Customer)

    What is the significance of GPR161 in signaling pathways? Oct 08 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR161 plays a central role in suppressing Hedgehog signaling, and its mislocalization or mutation can lead to developmental defects and cancers. It is also involved in regulating retinoic acid and canonical Wnt pathways during neurulation. Oct 08 2022

    chat Laura (Verified Customer)

    How is GPR161 associated with cancer? Dec 25 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GPR161 is overexpressed in certain types of breast cancer and promotes cell proliferation and invasion. It forms a signaling complex with certain proteins, playing a significant role in cell signaling pathways associated with cancer progression​​. Dec 25 2022

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    • mProX™ Human GPR161 Stable Cell Line (CAT#: S01YF-0923-PY175)
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