mProX™ Human GPR151 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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Published Data
Fig.1 Experimental validation of GPR151 function in adipogenesis.
The left panel displays Oil-Red O staining results, while the right panel illustrates the quantification of lipid droplets in adipocytes that underwent either scRNA or siGpr151 transfection, observed at a ×10 magnification with a 100 μm scale bar. The analysis involved 10 independent cell cultures for scRNA and 12 for siGpr151, with the presentation of means ± SEM (***p-value < 0.001, **p-value < 0.01, *p-value < 0.05). The term "scRNA" pertains to scrambled siRNA in this context.
Ref: Tanigawa, Yosuke, et al. "Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology." Nature communications 10.1 (2019): 4064.
Pubmed: 31492854
DOI: 10.1038/s41467-019-11953-9
Research Highlights
Xu H, et al. "Deep learning-based classification model for GPR151 activator activity ." BMC bioinformatics, 2023.
The protein GPR151, a member of the G protein-coupled receptor family, has been linked to various physiological and pathological processes. Recent studies have shown its potential as a therapeutic target for metabolic disorders, emphasizing the need to investigate its activators. As drug discovery can be time-consuming and costly, a reliable activity classification model is crucial. The authors propose a learning-based approach using a feature extractor and deep neural network to predict GPR151 activators. Experiments with their own dataset demonstrate high accuracy and stability, with their optimal model significantly improving upon traditional methods. This suggests promising applications for their approach in activity prediction and drug discovery.
Pubmed:
37296398
DOI:
10.1186/s12859-023-05369-y
von Breitenbuch P, et al. "Expression of pH-Sensitive GPCRs in Peritoneal Carcinomatosis of Colorectal ." Journal of clinical medicine, 2023.
The altered metabolism of solid tumors, with a decreased extracellular pH and increased intracellular pH, has been found to affect tumor cell migration and proliferation through proton-sensitive ion channels and G protein-coupled receptors (pH-GPCRs). However, the expression of these pH-GPCRs in peritoneal carcinomatosis, a rare form of cancer, is currently unknown. In this study, the expression of GPR4, GPR65, GPR68, GPR132, and GPR151 was investigated in paraffin-embedded tissue samples from 10 patients with peritoneal carcinomatosis of colorectal origin. GPR4 expression was weak in only 30% of samples, significantly lower than GPR56, GPR132, and GPR151. GPR68 was expressed in 60% of tumors, with significantly reduced expression compared to GPR65 and GPR151. This is the first study exploring pH-GPCRs in peritoneal carcinomatosis, and the findings suggest lower expression of GPR4 and GPR68 compared to other pH-GPCRs in this cancer type, potentially paving the way for future therapies targeting either the tumor microenvironment or these specific GPCRs.
Pubmed:
36902589
DOI:
10.3390/jcm12051803
