mProX™ Human GPBAR1 Stable Cell Line

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

GPBAR1, also known as TGR5, is a G-protein-coupled bile acid receptor that has been the focus of numerous scientific studies due to its diverse physiological roles. Recent research has highlighted the importance of GPBAR1 in the context of metabolic and inflammatory diseases. For instance, studies have shown that activation of GPBAR1 can lead to the secretion of GLP-1, a hormone that plays a pivotal role in glucose homeostasis. Furthermore, GPBAR1 has been linked to the modulation of bile acid signaling pathways, which are crucial for lipid metabolism and energy expenditure. In the realm of liver diseases, GPBAR1 agonists have demonstrated protective effects against the development of steatosis and fibrosis. Moreover, there is evidence suggesting that GPBAR1 plays a role in the progression of certain cancers, such as gallbladder carcinoma, by modulating specific signaling pathways. Additionally, the receptor has been associated with the regulation of ACE2 expression in the context of inflammation, potentially linking it to infectious diseases like COVID-19. In summary, GPBAR1 has emerged as a promising therapeutic target with applications ranging from metabolic disorders to inflammation and cancer.