GPBAR1
A member of the G protein-coupled receptor (GPCR) superfamily is encoded by this gene. This enzyme serves as a bile acid receptor on the cell surface. Bile acid treatment causes the internalization of the receptor, generation of intracellular cAMP, and activation of a MAP kinase signaling pathway in cells that express this GPCR. The receptor is thought to play a role in how bile acids control energy homeostasis and decrease macrophage activity. Sclerosing cholangitis and intrahepatic cholestasis of pregnancy are two conditions linked to GPBAR1. ADORA2B-mediated anti-inflammatory cytokine production and Class A/1 are two of its associated mechanisms (Rhodopsin-like receptors). G protein-coupled receptor activity and G protein-coupled bile acid receptor activity are two Gene Ontology (GO) annotations connected to this gene.
| Full Name | G protein-coupled bile acid receptor 1 |
| Gene ID | Human: 151306 Mouse: 227289 Rat: 338443 Monkey: 103217859 |
| UniProt ID | Human: Q8TDU6 Mouse: Q80SS6 Rat: Q80T02 Monkey: A0A5F7ZTP7 |
| Alternative Names | BG37; TGR5; M-BAR; GPCR19; GPR131; G-protein coupled bile acid receptor 1; G-protein coupled bile acid receptor BG37; G-protein coupled receptor GPCR19; membrane bile acid receptor; membrane-type receptor for bile acids; GPBAR1; G protein-coupled bile acid receptor 1 |
Product List
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- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GPBAR1 Target Family: Bile Acid Target Protein Species: Rat Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: cAMP assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GPBAR1 Target Family: Bile Acid Target Protein Species: Mouse Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: cAMP assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GPBAR1 Target Family: Bile Acid Target Protein Species: Human Protein Tag: FLAG-tag at N-terminus Host Cell Type: CHO-K1 Assay Types: cAMP assay
- Product Category:
- Membrane Protein Stable Cell Lines
- Target Protein: GPBAR1 Target Family: Bile Acid Family Target Protein Species: Human Host Cell Type: SW1353;CHO-K1;HEK293
