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  • mProX™ Human GHSR Stable Cell Line

    [CAT#: S01YF-0923-PY74]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    GHSR
    Target Family
    Ghrelin Family
    Target Protein Species
    Human
    Host Cell Type
    HUVECs;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Metabolic Research
    Related Diseases
    Growth Hormone Deficiency, Isolated Partial;Gastroparesis
    Gene ID
    Human: 2693
    UniProt ID
    Human: Q92847

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The Growth Hormone Secretagogue Receptor (GHSR) plays a pivotal role in energy homeostasis, appetite regulation, and metabolic processes. Recent studies have highlighted the significance of GHSR in the neuroendocrine response during prolonged fasting. Additionally, GHSR has been implicated in the pathophysiology of alcohol dependence, suggesting its potential as a therapeutic target. Furthermore, GHSR signaling has been shown to inhibit high glucose-induced retinal angiogenesis, providing insights into potential therapeutic strategies for diabetic retinopathy.

    Protocols

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    FAQ

    chat James (Verified Customer)

    What is the significance of GHSR in regulating energy homeostasis? Jan 17 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GHSR, also known as the growth hormone secretagogue receptor, plays a crucial role in energy homeostasis by mediating the orexigenic effects of ghrelin, which can influence food intake and energy expenditure. Jan 17 2023

    chat James (Verified Customer)

    How does GHSR interact with other metabolic pathways? Mar 21 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GHSR can interact with various metabolic pathways, including those involved in glucose metabolism, lipid metabolism, and mitochondrial function, thereby influencing overall metabolic health. Mar 21 2023

    Published Data

    Fig.1 Adenoviral GHSR-1a promotes angiogenesis and tube formation.

    Tube formation by human umbilical endothelial cells (HUVECs) was evaluated in regular culture conditions and under ischemic stress post-adenoviral transfection of either GHSR-1a or a control plasmid for a 24-hour period. Scale bars measure 50 µm. Notably, *P<0.05 was observed compared to Ad-null during hypoxic conditions.

    Ref: Yuan, Ming-Jie, et al. "GHSR-1a is a novel pro-angiogenic and anti-remodeling target in rats after myocardial infarction." European journal of pharmacology 788 (2016): 218-225.

    Pubmed: 27343377

    DOI: 10.1016/j.ejphar.2016.06.032

    Research Highlights

    Beheshti S, et al. "Differential impact of a ghrelin receptor antagonist or inverse agonist in the ." Epilepsy research, 2023.
    The peptide ghrelin has been found to have an effect on seizures, but there is no consensus on its exact influence in controlling seizure severity. A study was conducted to assess the effect of a ghrelin receptor antagonist and inverse agonist on seizures induced by electrical kindling. In adult male rats, electrodes were implanted in the skull or the basolateral amygdala, and a rapid kindling protocol was used. The rats were treated with either D-Lys-3-GHRP-6 or [D-Arg, D-phe, D-Trp, heu] substance P (D-SP) as the antagonist or inverse agonist, respectively. The results showed that antagonism of the ghrelin receptor in the amygdala increased seizure induction in a dose-dependent manner and led to spontaneous seizures. On the other hand, D-SP had a dose-dependent anticonvulsant effect, as evidenced by a decrease in seizure duration. These findings suggest that different GHSR ligands may have varying effects on seizure control, highlighting the importance of considering the specific ghrelin system in modulation of seizures.
    Pubmed: 37793283   DOI: 10.1016/j.eplepsyres.2023.107234

    Ringuet MT, et al. "Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin ." The Journal of physiology, 2023.
    In this study, the effects of dopamine, 5-hydroxytryptamine (5-HT), and ghrelin receptor agonists on colorectal motility were investigated. It was hypothesized that these agonists act on parasympathetic preganglionic neurons (PGNs) in the lumbosacral spinal cord. The researchers aimed to identify which specific neurons in this region express these receptors, their neuronal inputs, and if these agonists stimulate them. The results revealed that dopamine, serotonin, and ghrelin receptor transcripts are present in the same PGNs, and that these neurons have closely associated tyrosine hydroxylase and serotonin boutons. Whole cell electrophysiology experiments showed that these agonists induce an inward excitatory current in overlapping populations of lumbosacral PGNs. Furthermore, the excitatory effects of dopamine were reversed by GHSR antagonism, indicating that ghrelin receptors modulate dopamine effects at D2 receptors. These findings suggest that lumbosacral PGNs are the site at which actions of these endogenous ligands converge, and that ghrelin receptors play a regulatory role in dopaminergic signaling.
    Pubmed: 37772438   DOI: 10.1113/JP285217

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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