Ghrelin Family Related Drug Discovery Products
Membrane protein stable cell lines are widely used in many areas of biomedical research. Creative Biolabs can offer membrane protein stable cell lines to stablish in vitro models for High Throughput Screening.
Creative Biolabs offers high-quality, innovative tools to help research groups accelerate membrane protein drug discovery. They can be found by targets. If there is no product that meets your needs, please contact us.
The 7 transmembrane ghrelin receptor is involved in a number of physiological processes, including the release of growth hormone, increased food intake and fat storage, as well as the control of reward and cognitive processes. The ghrelin receptor has been a crucial therapeutic target in the development of anti-obesity drugs because of its crucial involvement in metabolism and energy expenditure. The Gq, Gi/o, G12/13, and arrestin recruitment signaling pathways are only a few of the communication channels that the ghrelin receptor can use to communicate. Because there are so many signaling pathways, it is possible for one signaling pathway to be preferred over another by ligands or receptor alterations.
Fig.1 Multiple signaling pathways of the ghrelin receptor. (Hedegaard & Holst, 2020)
Creative Biolabs offers a range of ghrelin family in vitro assays and products with our high-efficient drug discovery strategy in a timely and cost-effective manner:
Overview of Ghrelin Family
Both central and peripheral organs express the ghrelin receptor in all tissues. Mammalian GHSR is most highly expressed in the hypothalamus, then the pituitary, in the brain, which is consistent with its function in regulating hunger, food intake, and energy balance in the hypothalamus and GH production in the pituitary. The ARC of the hypothalamus, which is essential for neuroendocrine and appetite-stimulating functions, is where the GHSR1a is most abundantly expressed. The pituitary gland, hypothalamus, pancreas, spleen, stomach, intestine, heart, thyroid, gonads, adrenal, kidney, adipose tissue, vasculature, as well as a number of endocrine and endocrine cancers and cell lines, all express GHSR. The biological action of ghrelin is reinforced by its peripheral and extrahypothalamic expression, which goes beyond GH secretion and energy homeostasis.
Fig.2 Ghrelin mediated physiological functions. (Sivertsen, 2013)
Ghrelin Family Drug Discovery
Due to its significant influence on caloric intake and energy expenditure, the GHSR makes for an intriguing therapeutic target. The GHSR system also regulates neuropsychiatric activities like mood, reward behavior, cognitive functions, and GH secretion, which complicates the medication development process. Current in vitro and in vivo studies that demonstrate the principle of functionally biased GHSR ligand development show that it is possible to modulate a specific subset of the potential GHSR signaling pathways, providing a path to the development of GHSR drugs that minimize these potential side effects.
References
- Hedegaard, M.A., & Holst, B. The complex signaling pathways of the ghrelin receptor. Endocrinology. 2020, 161(4).
- Sivertsen, B.; et al. Functionally biased signaling properties of 7TM receptors–opportunities for drug development for the ghrelin receptor. British journal of pharmacology. 2013, 170(7): 1349-1362.
