mProX™ Human GHRHR Stable Cell Line
[CAT#: S01YF-0923-KX62]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
GHRHR
Target Family
Growth Hormone Releasing Hormone Receptor Family
Target Protein Species
Human
Host Cell Type
CHO-K1; HEK293
Target Classification
GPCR Cell Lines
Target Research Area
CNS Research
Related Diseases
Isolated Growth Hormone Deficiency, Type Iv; Isolated Growth Hormone Deficiency, Type Ib
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
GHRHR is a GPCR with seven hydrophobic transmembrane domains. GHRH binds to the GHRHR, which is predominately found on the pituitary somatotrope, after being released from the hypothalamus. The somatotrope becomes depolarized as a result of sodium channel opening brought on by GHRHR activation. A voltage-gated calcium channel is subsequently opened by the resulting alteration in intracellular voltage, letting calcium to enter the cell. This in turn triggers the release of prepared GH that has been stored in secretory granules. As a result of the cAMP rise, protein kinase A is stimulated, and it phosphorylates and activates the transcription factor cAMP response element binding protein, which in turn induces the manufacture of de novo GH. Mutations in the GHRHR that are autosomal recessive can cause a nearly complete lack of GH, short stature in humans, and the small phenotype in mice. The customized GHRHR stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Ernest
The cell line was exactly what I was looking for.
Oct 04 2022
Verified Customer
Janice
I was so pleased with the service I received from this business.
Apr 17 2023
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
