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    mProX™ Human GCGR Stable Cell Line

    [CAT#: S01YF-0923-PY76]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
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    Product Information

    Target Protein
    GCGR
    Target Family
    Glucagon Family
    Target Protein Species
    Human
    Host Cell Type
    HT29;SW480;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Digestive and Renal Research;CNS Research
    Related Diseases
    Mahvash Disease;Hypoglycemia
    Gene ID
    Human: 2642
    UniProt ID
    Human: P47871

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The Glucagon Receptor (GCGR) plays a pivotal role in glucose homeostasis and metabolic regulation. Recent research has highlighted the therapeutic potential of GCGR/GLP-1R dual agonists, such as BI 456906, which exhibit robust anti-obesity efficacy by modulating energy expenditure and food intake. Moreover, glucagon signaling via GCGR has been shown to reduce cell viability in liver cancer cells without stimulating gluconeogenic gene expression, suggesting a potential tumor suppressive role for glucagon/GCGR in liver cancer. Additionally, the dual agonist Cotadutide has demonstrated resolution of NASH and hepatic fibrosis by modulating mitochondrial function and lipogenesis.

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    There are currently no Customer reviews or questions for mProX™ Human GCGR Stable Cell Line (S01YF-0923-PY76). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Dorothy (Verified Customer)

    What is the primary function of GCGR in glucose metabolism? Mar 04 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GCGR, or glucagon receptor, mediates the effects of glucagon, a hormone that raises blood glucose levels by promoting glycogen breakdown and gluconeogenesis in the liver. Mar 04 2022

    chat Stephanie (Verified Customer)

    How does GCGR dysfunction relate to diabetes? Dec 10 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Dysregulation or dysfunction of GCGR can lead to impaired glucose homeostasis, contributing to the development of type 2 diabetes. Dec 10 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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