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    mProX™ Human GABRA4 Stable Cell Line

    [CAT#: S01YF-1123-KX67]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Ion Channel Cell Lines

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    Product Information

    Target Protein
    GABRA4
    Target Family
    GABAA
    Target Protein Species
    Human
    Host Cell Type
    CHO-K1; HEK293
    Target Classification
    Ion Channel Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Status Epilepticus; Autism
    Gene ID
    2557
    UniProt ID
    P48169

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The GABRA4 gene in humans codes for the protein known as gamma-aminobutyric acid receptor subunit alpha-4. In a study, mice with the wild-type and knockout GABRA4 genes were compared. It was discovered that traits linked to autism spectrum disorder (ASD) were seen when the GABRA4 gene was removed. Compared to wild-type mice, they include reduced social engagement and enhanced spatial cognition. An examination of the hippocampus transcriptome in knockout mice revealed elevated N-methyl-D-aspartate receptor activation. This contributes to consciousness and the learning that leads to those traits. The customized GABRA4 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

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    FAQ

    chat Rebecca (Verified Customer)

    How is GABRA4 associated with Alzheimer's Disease and other neurological disorders? Mar 21 2020

    chat Sherry Smith (Creative Biolabs Scientific Support)

    A severe reduction of GABRA4 has been observed in a subset of patients with Alzheimer's Disease (AD) and Parkinson's Disease (PD). Mar 21 2020

    chat Nancy (Verified Customer)

    What is the role of GABRA4 in melanoma suppression? Aug 22 2023

    chat Sherry Smith (Creative Biolabs Scientific Support)

    GABRA4 is inhibited by endogenous DOPA, which regulates melanocyte proliferative capacity and susceptibility to malignant transformation, indicating a potential role in melanoma suppression. Aug 22 2023

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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