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    mProX™ Human FOLR1 Stable Cell Line

    [CAT#: S01YF-1023-PY302]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:

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    Product Information

    Target Family
    Other Targets
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1
    Target Classification
    Other Targets Drug Discovery Assays and Products
    Target Research Area
    Metabolic Research
    Related Diseases
    Neurodegeneration Due To Cerebral Folate Transport Deficiency; Neurodegenerative Syndrome Due To Cerebral Folate Transport Deficiency
    Gene ID
    Human:2348
    UniProt ID
    Human:P15328

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    FOLR1, also known as folate receptor alpha, has various applications in different medical fields. In pediatric patients with developmental epileptic encephalopathy, targeted next-generation sequencing using FOLR1 helps identify genetic mutations associated with the disorder. In the context of craniofacial neuropathic pain, an epigenetic HDAC5 inhibitor that targets FOLR1 has been shown to reverse pain-related behaviors in mice. FOLR1 is also a therapeutic target in ovarian cancer, with various modalities such as antibody-drug conjugates and small molecules being explored for treatment. Additionally, FOLR1 plays a role in stroke susceptibility, as the genotype of Stim1 and the proximal region on chromosome 1 can have opposite effects on stroke susceptibility in stroke-prone spontaneously hypertensive rats. In laryngeal carcinoma, FOLR1-stabilized β-catenin promotes cancer progression through the EGFR/AKT/GSK-3β pathway. Understanding the function and clinical efficacies of FOLR1 in these different contexts is important for diagnosis, treatment, and genetic counseling.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human FOLR1 Stable Cell Line (S01YF-1023-PY302). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Jordan Smith (Verified Customer)

    What is the role of FOLR1 in cancer cells? Dec 01 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    FOLR1, a folate receptor, is overexpressed in various cancer types and is targeted by therapies like antibody-drug conjugates for its potential antitumor effects. Dec 01 2022

    chat Taylor Garcia (Verified Customer)

    How does FOLR1 contribute to cellular processes? Mar 28 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    FOLR1 is involved in folate transport, playing a crucial role in processes like cell growth and replication, particularly in rapidly dividing cells. Mar 28 2023

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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