mProX™ Human F2RL3 Stable Cell Line

Product Information

Target Protein

F2RL3

Target Family

Protease-activated (Thrombin) Family

Target Protein Species

Human

Host Cell Type

CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Cancer Research; Inflammation Research; Cardiovascular Research

Related Diseases

Asthma; Lung Cancer

Gene ID

9002

UniProt ID

Q96RI0

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

The F2RL3 gene in humans encodes the protein known as protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3. A member of the vast family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins is the coagulation factor II (thrombin) receptor-like 3 (F2RL3). Another member of the protease-activated receptor family is F2RL3. The extracellular amino terminus of F2RL3 is cleaved by proteases, which activates the protein. The new amino terminus activates the receptor by acting as a tethered ligand. Thrombin and trypsin both activate F2RL3. The customized F2RL3 stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

chat Rachel

mProX™ Human F2RL3 Stable Cell Line is very good! Sep 21 2022

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chat Christopher

We are satisfied with this F2RL3 cell line and we will use it in our experimental projects. Mar 21 2023

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FAQ

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Published Data

Fig.1 F2R and F2RL3 myometrial protein expression increased at labor in comparison.

Western blot of the expression of the protein F2RL3 (36 kDa molecular weight) in the human myometrium during pregnancy and labor. The relevant labeling located above each blot indicates the myometrial state.

Ref: O'Brien, Margaret, John J. Morrison, and Terry J. Smith. "Expression of prothrombin and protease activated receptors in human myometrium during pregnancy and labor." Biology of reproduction 78.1 (2008): 20-26.

Pubmed: 17901076

DOI: 10.1095/biolreprod.107.062182

Research Highlights

These results suggested that, particularly in later age, F2RL3 methylation is a highly powerful predictor of lung cancer risk and mortality. Further research is necessary to determine the possible effects of F2RL3 methylation on lung cancer prevention, risk stratification, and early detection.
Zhang, Yan, et al. "F2RL3 methylation, lung cancer incidence and mortality." International journal of cancer 137.7 (2015): 1739-1748.
Pubmed: 25821117 DOI: 10.1002/ijc.29537

Smoking-related epigenetic DNA hypomethylation at F2RL3 seems to boost PAR4 expression, which could have an impact on platelet reactivity in the future.
Corbin, Laura J., et al. "Epigenetic regulation of F2RL3 associates with myocardial infarction and platelet function." Circulation research 130.3 (2022): 384-400.
Pubmed: 35012325 DOI: 10.1161/CIRCRESAHA.121.318836