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    mProX™ Human EDNRB Stable Cell Line

    [CAT#: S01YF-0923-PY65]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Host Cell Type:
    Membrane Protein Engineering:
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    Product Information

    Target Protein
    EDNRB
    Target Family
    Endothelin Family
    Target Protein Species
    Human
    Host Cell Type
    MDA-MB-231;BT549;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Digestive and Renal Research;CNS Research
    Related Diseases
    Waardenburg Syndrome, Type 4A;Abcd Syndrome
    Gene ID
    Human: 1910
    UniProt ID
    Human: P24530

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    EDNRB is another critical receptor in the endothelin system. It has been associated with Hirschsprung-associated enterocolitis, where certain bacterial strains can activate specific signaling pathways in EDNRB-deficient models. Moreover, EDNRB mutations have been linked to Hirschsprung disease, a congenital disorder affecting the colon. Recent genetic studies have also identified novel variants in the EDNRB gene associated with Waardenburg syndrome, a genetic condition causing hearing loss and changes in pigmentation.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human EDNRB Stable Cell Line (S01YF-0923-PY65). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Gary (Verified Customer)

    How does EDNRB contribute to developmental research? Sep 12 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    EDNRB, or endothelin receptor type B, has been studied for its role in developmental disorders, particularly Hirschsprung disease. Mutations in the EDNRB gene can lead to defects in enteric neuron development, resulting in gastrointestinal dysfunction. Understanding the role of EDNRB in development can provide insights into congenital disorders and potential therapeutic interventions. Sep 12 2021

    chat David (Verified Customer)

    What is the significance of EDNRB in vascular remodeling? May 11 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    EDNRB, in conjunction with EDNRA, has been implicated in pathological vascular remodeling. Agents like andrographolide that modulate the endothelin signaling pathway have shown promise in regulating vascular remodeling by influencing the expression of both EDNRA and EDNRB. This suggests a coordinated role for these receptors in vascular health and disease. May 11 2023

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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