mProX™ Human DRD4 Stable Cell Line

Mostafalou S, Abdollahi M. "The susceptibility of humans to neurodegenerative and neurodevelopmental ." Archives of toxicology, 2023.
The field of toxicology investigates the effects of organophosphorus (OP) compounds on human health. These substances have been linked to an increased likelihood of neurological disorders, such as neurodegenerative and neurodevelopmental diseases. This review examines various studies on the role of OP compounds in the development of these disorders and explores how genetic variations can impact susceptibility to their neurotoxic effects. Research has shown that exposure to OP compounds can lead to the development of conditions like Alzheimer's disease, Parkinson's disease, attention deficit hyperactivity disorder, autism, intellectual disability, and other developmental neurotoxicities. In addition to inhibiting the cholinesterase enzyme, it is believed that OP compounds contribute to these disorders through other pathological mechanisms at both the extracellular and intracellular levels. Certain genetic polymorphisms, including PON1, ABCB1, NOS, DRD4, GST, CYP, and APOE, have been linked to an increased risk of developing OP-related neurological disorders.
Pubmed: 37787774   DOI: 10.1007/s00204-023-03604-2

Estandia A, et al. "Candidate gene polymorphisms are linked to dispersive and migratory behaviour: ." Journal of evolutionary biology, 2023.
In a study of partial migrant populations, research found that individuals who migrated typically displayed longer microsatellite alleles at the CLOCK gene compared to resident individuals within the same group. Further analysis revealed that populations which had been recently colonized (within 200 years) showed longer average microsatellite allele lengths at CREB1, compared to populations with a longer evolutionary history. However, Bayesian broken stick regression models demonstrated a decrease in CREB1 length over time since colonization. Similar patterns were observed for DRD4, although a larger sample size is needed for confirmation. While genes ADCYAP1, SERT, and NPAS2 showed variability, this was not linked to dispersal behavior. These findings suggest a potential link between genetic variants at these specific genes and the ability for migration and dispersal in silvereyes, and highlight the need for further investigation into the genetic mechanisms underlying these behaviors. It also presents an opportunity to solve an evolutionary paradox using a genetic approach.
Pubmed: 37750610   DOI: 10.1111/jeb.14222