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    mProX™ Human DRD4 Stable Cell Line

    [CAT#: S01YF-0923-PY62]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Based on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.

    Sub Cat Product Name Target Protein Species Host Cell Type Assay Types Inquiry Datasheet
    S01YF-1122-KX413 Magic™ Rat DRD4 in Vitro [35S]GTPγS binding Assay Rat CHO-K1 [35S]GTPγS binding Assay
    S01YF-1122-KX414 Magic™ Rat DRD4 in Vitro Radioligand Binding Assay Rat CHO-K1 Radioligand Binding Assay

    Product Information

    Target Protein
    DRD4
    Target Family
    Dopamine Family
    Target Protein Species
    Mouse
    Host Cell Type
    RAW;264.7;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Attention Deficit-Hyperactivity Disorder;Autonomic Nervous System Disease
    Gene ID
    Mouse: 13491
    UniProt ID
    Mouse: P51436

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    The Dopamine Receptor D4 (DRD4) has garnered attention in the realm of scientific research due to its association with various behavioral and neurological conditions. One study highlighted its role in antisaccade performance, suggesting two modes of antisaccade processing influenced by the DRD4 genotype. Furthermore, research has linked specific combinations of variants in the DRD4 gene with eating disorders, emphasizing its potential role in psychopathological features. Additionally, DRD4 has been implicated in the regulation of functional integration of brain networks in children with ADHD. The multifaceted implications of DRD4 in health and disease make it a crucial subject in scientific investigations.

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    FAQ

    chat Joseph (Verified Customer)

    What is the significance of DRD4 in scientific research? Feb 11 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    DRD4, also known as the dopamine receptor D4, plays a pivotal role in various neurological and psychological processes. It has been extensively studied for its association with attention-deficit hyperactivity disorder (ADHD) and its potential influence on novelty-seeking behavior. The receptor's polymorphisms, especially the variable number tandem repeats (VNTRs) in the third exon, have been linked to differences in human behavior and susceptibility to certain psychiatric disorders. Moreover, DRD4 has been implicated in the modulation of synaptic plasticity and cognition, making it a focal point in neuroscientific research. Feb 11 2022

    chat Sandra (Verified Customer)

    How does DRD4 contribute to our understanding of neuropsychiatric disorders? Mar 13 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The genetic variations in DRD4, particularly the 7-repeat allele of the VNTR, have been associated with ADHD, making it a potential therapeutic target1. Furthermore, its involvement in the dopamine pathway suggests its role in reward and motivation systems of the brain. Understanding the function and regulation of DRD4 can provide insights into the neurochemical basis of behavior and offer avenues for targeted treatments in neuropsychiatric conditions. Mar 13 2023

    Related Products by Target
    • mProX™ Human DRD4 Stable Cell Line (CAT#: S01YF-0923-PY62)
    • Magic™ Human DRD4 CHO-K1 Cell Line, Binding and Functional Assay (CAT#: S01YF-1222-KX224)
    • Magic™ Human FLAG tagged DRD4 HEK293T Gαqi5 Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX303)
    • Magic™ Human FLAG tagged DRD4 HEK293T Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX302)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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