mProX™ Human DRD3 Stable Cell Line

Salminen SP, et al. "Genetic risk scores associated with temperament clusters in Finnish depression ." Acta neuropsychiatrica, 2023.
Cloninger's temperament dimensions have been extensively studied in relation to genetics. The present study examined the associations between Cloninger's temperament dimensions and single nucleotide polymorphisms (SNPs) through cluster analyses. It involved 212 genotyped Finnish patients from the Ostrobothnia Depression Study. Selected depression-related genes were analyzed, and a total of 59 SNPs from ten genes were investigated. No significant associations were found between individual SNPs and temperament clusters. However, multivariate models and genetic risk score (GRS) analyses revealed significant associations between GRSs and temperament clusters, with two SNPs from the DRD3, SLC6A2, SLC6A4, and HTR2A genes associated with the HHA/LRD/LP cluster at baseline and six weeks, and the HTR2A and COMT genes associated with the HP cluster at six weeks. These findings suggest that GRSs may be linked to an individual's temperament profile, and further research is needed to investigate the clinical implications of these clusters.
Pubmed: 37665031   DOI: 10.1017/neu.2023.33

Fitzgerald E, et al. "Sex and cell-specific gene expression in corticolimbic brain regions associated ." EBioMedicine, 2023.
The study reveals significant sex-specific differences in the prevalence, symptomatology, and course of psychiatric disorders. However, preclinical models have typically focused on male subjects, resulting in a limited understanding of the molecular mechanisms driving these differences. The authors conduct transcriptome-wide gene expression analysis in male and female rats within the corticolimbic system, identifying over 3000 differentially expressed genes (DEGs) in the nucleus accumbens medial shell (NAcS). Further analysis shows that these DEGs are enriched for gene ontology terms related to blood vessel morphogenesis and cell migration. Additionally, single nuclei RNA sequencing in the NAcS identifies widespread sex-specific expression, with upregulated genes in females enriched for synaptic function. Notably, these upregulated genes are also linked to psychiatric disorders in humans. These findings highlight the importance of considering sex- and cell-specific molecular profiles in understanding psychiatric disorders, particularly in the NAcS region. This study was supported by funding from the Hope for Depression Research Foundation (MJM).
Pubmed: 37549631   DOI: 10.1016/j.ebiom.2023.104749