mProX™ Human DRD2 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX406	Magic™ Mouse DRD2S in Vitro cAMP Assay	Mouse	CHO-K1	cAMP Assay
S01YF-1122-KX407	Magic™ Rat DRD2S in Vitro cAMP Assay	Rat	CHO-K1	cAMP Assay

Product Information

Target Protein

DRD2

Target Family

Dopamine Family

Target Protein Species

Human

Host Cell Type

HCT116;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Pain and Addiction Research;CNS Research

Related Diseases

Cocaine Dependence;Substance Dependence

Gene ID

Human: 1813

UniProt ID

Human: P14416

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

DRD2, the Dopamine receptor D2, is another subtype of dopamine receptors. It has been extensively studied for its role in various neurological and psychiatric disorders. Polymorphisms in the DRD2 gene have been associated with individual responses to psychiatric treatments, suggesting its importance in precision medicine. Moreover, DRD2 has been implicated in the progression of malignant tumors, especially under psychological stress conditions. The potential of DRD2 antagonists in enhancing the efficacy of chemoradiotherapy in certain cancers has also been explored. The multifaceted roles of DRD2 in the brain and its involvement in various diseases make it a focal point of scientific research.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Lisa (Verified Customer)

What is the role of DRD2 in scientific investigations? Jul 10 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

DRD2, or Dopamine receptor D2, is another receptor for dopamine and plays a complementary role to DRD1 in the brain's dopaminergic pathways. It is heavily implicated in reward and pleasure circuits, and its dysregulation is associated with conditions like addiction, schizophrenia, and certain types of tumors. Jul 10 2023

chat Jason (Verified Customer)

How does DRD2 influence therapeutic responses in certain conditions? Jan 27 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

DRD2 has been identified as a target for various therapeutic interventions, especially in psychiatric disorders. For instance, many antipsychotic drugs act by modulating DRD2 activity. Additionally, recent research has shown that DRD2 can influence the sensitivity of certain tumors to treatments, suggesting its potential role in cancer therapy. Jan 27 2023

Published Data

Fig.1 Temporary suppression of DRD2 expression within HCT116 cellular populations results in a diminishment of cell proliferation.

Temporarily diminishing DRD2 expression through siRNA resulted in reduced cell numbers, although ONC201 exhibited a markedly more potent impact on diminishing cell counts compared to DRD2 knockdown (*P < 0.05 vs. control shRNA-treated viability).

Ref: Kline, Christina Leah B., et al. "Role of dopamine receptors in the anticancer activity of ONC201." Neoplasia 20.1 (2018): 80-91.

Pubmed: 29216597

DOI: 10.1016/j.neo.2017.10.002

Research Highlights

Kuznetsov A, et al. "Genetic Contributors to PTSD: the Role of SNVs, Gene Interactions and Haplotypes ." Psychiatria Danubina, 2023.
Post-traumatic stress disorder (PTSD) is a condition that affects individuals who have experienced trauma or high levels of stress, and has a significant socioeconomic impact. The purpose of this review was to identify potential genetic markers associated with predisposition to PTSD, with the aim of informing future studies focused on developing prevention and treatment measures for the disorder. Through a search of the PubMed database, 20 articles were selected for analysis based on specific inclusion criteria. These studies revealed significant associations between PTSD and genetic variants of FKBP5, DRDsmall ha, ANNK1-COMT, OXTR-DRD2, and CRHR1. Although these findings provide some insight into the genetic factors involved in PTSD, further research, particularly into epigenetic mechanisms, is needed to fully understand the disorder and develop effective interventions.
Pubmed: 37800217 DOI: No

Santos LC, et al. "Kisspeptin treatment reverses high prolactin levels and improves gonadal function ." Scientific reports, 2023.
The authors conducted an evaluation to determine the potential of kisspeptin-10 (Kp10) administration in restoring gonadal function in male rats with hypothyroidism. Hypothyroidism was induced in the rats with 6-propyl-2-thiouracil (PTU) for three months. In the final month, half of the hypothyroid rats received Kp10 treatment. Results showed that hypothyroidism reduced testicular and sex gland mass, impaired sperm quality, and altered hormone levels. It also decreased the expression of certain proteins and hormones involved in reproductive function. However, treatment with Kp10 restored testicular and sex gland morphology, improved sperm quality, and normalized hormone levels. These findings suggest that Kp10 may be a potential treatment for hypothyroidism-induced changes in the male gonadal axis and sperm quality.
Pubmed: 37798396 DOI: 10.1038/s41598-023-44056-z