Recommended
Membrane Protein Drug Discovery In Vitro Assays Membrane Protein In Vitro Assay Kits Membrane Protein Stable Cell Lines Membranes Membrane Protein Virus Particles Membrane Staining and Imaging Reagents
  1. Home
  2. CYSLTR2
  3. mProX™ Human CYSLTR2 Stable Cell Line
product-img
  • Products
  • Discover MP Targets
  • Discover Research Areas
    • 1- Membrane Protein Stable Cell Line-DiscoverMP Membrane Protein Stable Cell Line, Drug Discovery Tools
    1- Membrane Protein Stable Cell Line-DiscoverMP GPCR Cell Lines,Drug Discovery Tools
    Family stable cell lines Leukotriene Family Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human CYSLTR2 Stable Cell Line

    [CAT#: S01YF-0923-PY95]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

    Datasheet MSDS Request COA

    Certificate of Analysis Lookup
    To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
    Lot Number

    Bulk Quote

    Made to Order Inquiry

    Inquiry
    Host Cell Type:
    Membrane Protein Engineering:
    Fluorescent Marker:
    Resistance:
    Deliverable:

    Product Information

    Target Protein
    CYSLTR2
    Target Family
    Leukotriene Family
    Target Protein Species
    Mouse
    Host Cell Type
    Melan-a;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Asthma;Melanoma, Uveal
    Gene ID
    Mouse: 70086
    UniProt ID
    Mouse: Q920A1

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CYSLTR2, a G-protein-coupled receptor, has been identified as a significant player in the pathogenesis of Uveal Melanoma (UM). A comprehensive bioinformatics analysis revealed the role of eight genes, including CYSLTR2, associated with the most common genetic anomalies in UM. Furthermore, CYSLTR2 has been implicated in both the early and late development of uveal melanoma, making mutant CysLT2R a promising therapeutic target. Another study concluded that the GPCR CysLTR2 mutant displays profound signaling bias for Gq/11 signaling pathways, suggesting its potential as a therapeutic target in uveal melanoma. Additionally, CYSLTR2-mutant melanocytic blue neoplasms frequently exhibit a heavily pigmented exophytic tumor, suggesting its involvement in melanocytic neoplasms4.

    Protocols

    Please visit our protocols page.

    Customer Reviews

    There are currently no Customer reviews or questions for mProX™ Human CYSLTR2 Stable Cell Line (S01YF-0923-PY95). Click the button above to contact us or submit your feedback about this product.

    FAQ

    chat Laura (Verified Customer)

    What is the significance of CYSLTR2 mutations in uveal melanoma? Aug 18 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Mutations in CYSLTR2, particularly the p.Leu129Gln substitution, have been identified in uveal melanoma samples that lacked mutations in other common genes such as GNAQ, GNA11, and PLCB4. These mutations are recurrent and activating, suggesting a potential role in the tumorigenesis of uveal melanoma. Aug 18 2023

    chat Patricia (Verified Customer)

    How does the CYSLTR2 mutation affect the signaling pathways in uveal melanoma? Mar 19 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The CYSLTR2 mutation, specifically the L129Q variant, displays profound signaling bias for Gq/11 signaling pathways. This mutation also escapes β-arrestin-mediated downregulation, which might contribute to the progression of uveal melanoma. Mar 19 2022

    Related Products by Target
    • Magic™ Human FLAG tagged CYSLTR2 HEK293T Cell Line, Calcium flux assay (CAT#: S01YF-1022-KX400)
    • mProX™ Human CYSLTR2 Stable Cell Line (CAT#: S01YF-0923-PY95)
    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
    Send Inquiry Send Inquiry
    Inquiry Basket
    compare

    Go to compare