mProX™ Human CYSLTR1 Stable Cell Line

Product Information

Target Protein

CYSLTR1

Target Family

Leukotriene Family

Target Protein Species

Human

Host Cell Type

SW480;HT-29;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research

Related Diseases

Exercise-Induced Bronchoconstriction;Asthma

Gene ID

Human: 10800

UniProt ID

Human: Q9Y271

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Cysteinyl leukotriene receptor 1 (CYSLTR1) is a pivotal player in the realm of scientific research, particularly in the context of inflammatory responses. It is predominantly involved in mediating the effects of cysteinyl leukotrienes, which are lipid mediators implicated in various inflammatory conditions. Notably, CYSLTR1 has been linked to the pathogenesis of asthma, where it plays a role in bronchoconstriction, vascular permeability, and mucus secretion. Furthermore, its association with allergic rhinitis underscores its significance in allergic reactions. The therapeutic potential of targeting CYSLTR1 is evident, with antagonists being developed to treat asthma and allergic diseases.

Protocols

Please visit our protocols page.

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FAQ

chat Christopher (Verified Customer)

What is the role of Cysteinyl Leukotriene Receptor-1 (CYSLTR1) in the immune system? May 05 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

Cysteinyl leukotrienes (cysLTs) are predominantly produced by cells of the innate immune system, such as basophils, eosinophils, mast cells, and monocytes/macrophages. They have a proinflammatory effect due to their interactions with G-protein-coupled receptors, including CYSLTR1, which are expressed on various cell types. These interactions contribute to the immunopathogenesis of several inflammatory disorders, especially bronchial asthma. May 05 2020

chat Ashley (Verified Customer)

How do CYSLTR1 antagonists affect the immune response? Jun 13 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

CYSLTR1 antagonists, including montelukast, pranlukast, and zafirlukast, have been developed to target the proinflammatory activities of cysLTs. Apart from their primary action as CYSLTR1 antagonists, these agents also possess secondary anti-inflammatory activities that are particularly effective against neutrophils and monocytes/macrophages. These secondary mechanisms involve interference with cyclic nucleotide phosphodiesterases, 5'-lipoxygenase, and the proinflammatory transcription factor, nuclear factor kappa B. Jun 13 2023

mProX™ Human CYSLTR1 Stable Cell Line

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