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    mProX™ Human CXCR5 Stable Cell Line

    [CAT#: S01YF-0923-PY48]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    CXCR5
    Target Family
    Chemokine Family
    Target Protein Species
    Human
    Host Cell Type
    ACHN;Caki-2;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Intraocular Lymphoma;Lymphoma
    Gene ID
    Human: 643
    UniProt ID
    Human: P32302

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CXCR5, another chemokine receptor, has been identified as a significant factor in various autoimmune diseases. The CXCL13/CXCR5 axis, in particular, has been discussed for its pathogenic roles in these diseases, suggesting CXCL13 as a potential biomarker and therapeutic target. In cancer research, the CXCL13/CXCR5 signaling has been found to modulate cancer and immune cells, promoting lymphocyte infiltration and increasing the antitumor immune response. Moreover, in rheumatoid arthritis progression, the CXCL13/CXCR5 axis has been shown to facilitate endothelial progenitor cell homing and angiogenesis. In the context of nasopharyngeal carcinoma, the induction of specific T cells links innate inflammation to immune privilege in tumor-associated tertiary lymphoid structures, indicating a potential therapeutic avenue.

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    FAQ

    chat Charles (Verified Customer)

    What is the significance of the CXCL13/CXCR5 axis in autoimmune diseases? Jun 18 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The CXCL13/CXCR5 axis plays a pathogenic role in autoimmune diseases, and CXCL13 has potential as a disease biomarker and therapeutic target in these conditions. Jun 18 2021

    chat Elizabeth (Verified Customer)

    How does the CXCL13/CXCR5 signaling influence cancer treatments, especially with immune checkpoint inhibitors? Jun 23 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    The CXCL13/CXCR5 signaling modulates cancer and immune cells to promote lymphocyte infiltration, activation by tumor antigens, and differentiation, thereby enhancing the antitumor immune response. Jun 23 2020

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