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    mProX™ Human CXCR3 Stable Cell Line

    [CAT#: S01YF-0923-PY46]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    CXCR3
    Target Family
    Chemokine Family
    Target Protein Species
    Human
    Host Cell Type
    HepG2;AML-12;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    Immunology Research
    Related Diseases
    Cutaneous Lupus Erythematosus;Pulmonary Sarcoidosis
    Gene ID
    Human: 2833
    UniProt ID
    Human: P49682

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CXCR3, another chemokine receptor, has been extensively studied for its role in immune responses, especially in the context of cancer and autoimmunity. The CXCL9, -10, -11/CXCR3 axis is known to regulate immune cell migration, differentiation, and activation, leading to tumor suppression. However, there are instances where this axis has been implicated in tumor growth and metastasis. In the realm of breast cancer, exercise training has been shown to improve tumor control by increasing CD8+ T-cell infiltration via CXCR3 signaling, thereby enhancing the efficacy of immune checkpoint blockade. Furthermore, CXCR3 ligands have been identified as crucial in directing the biological properties of CD4+ and CD8+ T cells in cancer and autoimmunity. Given its central role in modulating immune responses, CXCR3 and its ligands present potential therapeutic targets for various diseases, including cancer.

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    FAQ

    chat Timothy (Verified Customer)

    What is the role of CXCR3 in breast cancer cell migration? Dec 14 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    GNG4, which encodes the G-protein subunit γ-4, is induced following Cxcl10 treatment in breast cancer cells, suggesting a potential role in cell migration. Dec 14 2020

    chat Thomas (Verified Customer)

    How does CXCR3 signaling contribute to trigeminal neuropathic pain? Apr 17 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CXCL10 acts on CXCR3 to induce ERK and AKT activation in trigeminal ganglion neurons, contributing to the maintenance of trigeminal neuropathic pain. Apr 17 2020

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