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    mProX™ Human CTLA4 Stable Cell Line

    [CAT#: S01YF-1023-PY167]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    Immune Checkpoint Cell Lines

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    Product Information

    Target Family
    Immune Checkpoint
    Target Protein Species
    Human
    Host Cell Type
    HEK293;CHO-K1;H22
    Target Classification
    Immune Checkpoint Cell Lines
    Target Research Area
    Autoimmune Research;Immunology Research
    Related Diseases
    Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation; Celiac Disease 3
    Gene ID
    Human:1493
    UniProt ID
    Human:P16410

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    CTLA4, or cytotoxic T lymphocyte-associated protein-4, is a protein that plays a role in regulating the immune response. It is targeted by immunotherapy in various cancers. Recent studies have explored the applications of CTLA4 in different contexts. One study focused on the expansion of regulatory T cells (Treg) expressing HLA-DR and CD27 markers, which showed enhanced antigen-specific suppressive function. These Treg cells have potential for the treatment of autoimmune diseases and graft rejection. Another study investigated the role of CTLA4 in immune checkpoint inhibitor-induced colitis, showing that polyfunctional lymphocytes and the IL23/IFNγ axis are involved in mediating this condition. Additionally, CTLA4 was found to be overexpressed in a subset of prolactin- and growth hormone-secreting pituitary adenomas, suggesting a potential therapeutic target for immune checkpoint inhibitors in these tumors. Overall, these studies highlight the diverse applications of CTLA4 in immune regulation and cancer treatment.

    Protocols

    Please visit our protocols page.

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    FAQ

    chat Jordan Miller (Verified Customer)

    What is the prognostic value of SIGLEC9 in glioma? Jan 27 2023

    chat Patrick Liam (Creative Biolabs Scientific Support)

    High expression levels of SIGLEC9 in glioma are indicative of poor outcomes and correlate with immune cell infiltration, suggesting its potential as a diagnostic marker and immunotherapy target. Jan 27 2023

    chat Peyton Jones (Verified Customer)

    How does SIGLEC9 influence immune cell function in virus infection and tumor progression? Nov 18 2021

    chat Patrick Liam (Creative Biolabs Scientific Support)

    SIGLEC9, along with Siglec7, regulates the immune system against viruses and cancers, impacting natural killer cell functions and potentially influencing disease progression. Nov 18 2021

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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