Human CTLA4 Membrane Protein Mammalian Transient Expression Plasmid
[CAT#: S01YF-1124-KX383]
- Product Category:
- Membrane Protein Tools
- Subcategory:
- Membrane Protein Plasmids
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Information
Product Overview
This product is a made-to-order plasmid encoding human CTLA4 for Protein Expression.
Target Protein
CTLA4
Target Protein Species
Human
Target Classification
Immune Checkpoint
Target Research Area
Autoimmune Research; Immunology Research
Related Diseases
Immune Dysregulation With Autoimmunity; Immunodeficiency; And Lymphoproliferation; Celiac Disease
Target Family
Immune Checkpoint
Vector
pME
Vector Type
Mammalian Transient Expression Vector
Note
Resistance
AmpR
Growth Temperature
37°C
Relevant Promoters
CMV, SV40, EF1a, CAG etc.
Mutation
Based on specific requirements
Expressed Tags
Based on specific requirements (Flag, StrepII, His, etc.)
Product Properties
Applications
Protein Expression
Shipping
Blue Ice
Storage
Aliquot and store at -20°C for long term.
Target
Full Name
Cytotoxic T-lymphocyte associated protein 4
Introduction
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
Alternative Names
CTLA4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3; cytotoxic T-lymphocyte protein 4celiac disease 3; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte-associated serine esterase-4; insulin-dependent diabetes mellitus 12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; Cytotoxic T-lymphocyte associated protein 4
Gene ID
UniProt ID
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