mProX™ Human CRHR2 Stable Cell Line

Sub Cat	Product Name	Target Protein Species	Host Cell Type	Assay Types	Inquiry	Datasheet
S01YF-1122-KX394	Magic™ Rat CRF2a in Vitro cAMP Assay	Rat	CHO-K1	cAMP Assay

Product Information

Target Protein

CRHR2

Target Family

CRF Receptor Family

Target Protein Species

Human

Host Cell Type

NCM460;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Digestive and Renal Research

Related Diseases

Irritable Bowel Syndrome;Eating Disorder

Gene ID

Human: 1395

UniProt ID

Human: Q13324

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CRHR2, the Corticotropin-releasing hormone receptor 2, is another receptor involved in the stress response system. Unlike CRHR1, CRHR2 has been associated with anti-stress effects. Research has shown that activation of CRHR2 can lead to reduced anxiety-like behaviors. This receptor is predominantly found in the cardiovascular system, and its activation has cardioprotective effects, especially during conditions of ischemic heart disease. The potential of CRHR2 agonists in treating heart diseases and stress-related disorders makes it a significant focus of scientific research.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Matthew (Verified Customer)

What role does CRHR2 play in scientific research? Oct 15 2021

chat Patrick Liam (Creative Biolabs Scientific Support)

CRHR2, or Corticotropin-releasing hormone receptor 2, is another receptor involved in the body's stress response system. Scientific studies have shown that CRHR2 has distinct functions from CRHR1, particularly in the areas of cardiovascular regulation, inflammation, and feeding behavior. Its involvement in these processes makes it a subject of interest in research related to cardiovascular diseases, inflammatory conditions, and metabolic disorders. Oct 15 2021

chat Cynthia (Verified Customer)

How is CRHR2 associated with inflammation and feeding behavior? Dec 17 2022

chat Patrick Liam (Creative Biolabs Scientific Support)

CRHR2 has been found to modulate inflammatory responses in various tissues, suggesting its potential role in inflammatory diseases. Additionally, its expression in certain regions of the brain indicates its involvement in regulating feeding behavior, which can have implications for conditions like obesity and eating disorders. Dec 17 2022

Published Data

Fig.1 Stimulation of CRHR2 enhances colonic epithelial cell viability.

Enhanced CRHR2 expression within NCM460 cells affords protection against the detrimental effects of TNF-α, preventing the reduction in cellular viability.

Ref: Hoffman, Jill M., et al. "Corticotropin-releasing hormone receptor 2 signaling promotes mucosal repair responses after colitis." The American journal of pathology 186.1 (2016): 134-144.

Pubmed: 26597886

DOI: 10.1016/j.ajpath.2015.09.013

Research Highlights

Wang, et al. "Sodium butyrate facilitates CRHR2 expression to alleviate HPA axis hyperactivity in autism-like rats induced by prenatal lipopolysaccharides through histone deacetylase inhibition." Msystems (2023): e00415-23.
This study examined the impact of stress on cardiovascular health in middle-aged individuals. Information from surveys, physical examinations, and medical records was assessed for a sample of 500 participants between the ages of 45-60. Findings revealed a noteworthy association between stress levels and a heightened likelihood of developing cardiovascular disease, notably in the form of hypertension and heart attacks. This highlights the importance of managing stress in middle age for maintaining optimal cardiovascular well-being. Additional research is recommended to establish effective techniques for mitigating stress and enhancing cardiovascular outcomes.
Pubmed: 37815348 DOI: 10.1128/msystems.00915-23

Wang Y, et al. "Lidocaine ameliorates intestinal barrier dysfunction in irritable bowel syndrome ." Neurogastroenterology and motility, 2023.
Intestinal barrier dysfunction is a prevalent factor underlying various disorders. Despite previous research, there is no effective resolution currently available. Studies have shown that lidocaine may possess anti-inflammatory properties and can alleviate visceral hypersensitivity in individuals with irritable bowel syndrome (IBS). Therefore, this study aims to further investigate the effects of lidocaine on intestinal barrier dysfunction in IBS and to explore the underlying mechanisms. The researchers conducted experiments on rats subjected to water avoidance stress to mimic the symptoms of IBS and also conducted in vitro experiments using Caco-2 cells. The results showed that lidocaine improved intestinal permeability, restored tight junctions, and reduced inflammatory markers in the rats. It also enhanced the expression of corticotropin-releasing hormone receptor 2 (CRHR2) in intestinal epithelial cells. The findings suggest that lidocaine may improve intestinal barrier dysfunction in IBS by modulating the expression of CRHR2.
Pubmed: 37736684 DOI: 10.1111/nmo.14677