mProX™ Human CRHR1 Stable Cell Line

Product Information

Target Protein

CRHR1

Target Family

CRF Receptor Family

Target Protein Species

Mouse

Host Cell Type

bEnd3;CHO-K1;HEK293

Target Classification

GPCR Cell Lines

Target Research Area

CNS Research;Digestive and Renal Research

Related Diseases

Irritable Bowel Syndrome;Anxiety

Gene ID

Mouse: 12921

UniProt ID

Mouse: P35347

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CRHR1, or Corticotropin-releasing hormone receptor 1, is a receptor that plays a pivotal role in the stress response system. In scientific research, CRHR1 has been extensively studied for its involvement in stress-related disorders, including depression and anxiety. Recent studies have shown that CRHR1 antagonists can be potential therapeutic agents for treating depression and anxiety disorders. These antagonists work by blocking the action of CRH, thereby reducing the stress response and alleviating symptoms of these disorders. Moreover, CRHR1 has also been linked to alcohol consumption behaviors, suggesting its potential role in alcohol use disorders. Understanding the molecular mechanisms and pathways involving CRHR1 can pave the way for novel therapeutic interventions for various stress-related conditions.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Linda (Verified Customer)

What is the significance of CRHR1 in the context of scientific research? Feb 21 2020

chat Patrick Liam (Creative Biolabs Scientific Support)

CRHR1, also known as Corticotropin-releasing hormone receptor 1, plays a pivotal role in the stress response system. In scientific research, it has been identified as a key receptor involved in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, which is responsible for the body's response to stress. Dysregulation of this receptor can lead to various psychiatric and neurological disorders, making it a potential therapeutic target. Feb 21 2020

chat Cynthia (Verified Customer)

How does CRHR1 influence the body's response to stress? Aug 25 2023

chat Patrick Liam (Creative Biolabs Scientific Support)

CRHR1 mediates the release of corticotropin-releasing hormone (CRH), which in turn stimulates the release of adrenocorticotropic hormone (ACTH) from the pituitary gland. This cascade eventually leads to the secretion of cortisol, a stress hormone, from the adrenal glands. Any alteration in the function of CRHR1 can disrupt this cascade, potentially leading to disorders related to stress response. Aug 25 2023

mProX™ Human CRHR1 Stable Cell Line

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