mProX™ Human CNR1 Stable Cell Line

Lu C, et al. "Associations between polymorphisms in the cannabinoid receptor 1 gene, cognitive ." Brain research, 2023.
In this study, researchers aimed to investigate the potential relationship between single nucleotide polymorphisms (SNPs) of the CNR1 gene and both the development of tardive dyskinesia (TD) and cognitive impairments in a Chinese population with schizophrenia (SCZ). A total of 216 SCZ patients were recruited and divided into two groups based on the presence or absence of TD. The severity of TD was assessed using the Abnormal Involuntary Movement Scale (AIMS) and cognitive function was measured using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS) scale. Statistical analyses were carried out using SHE-sis software, and an analysis of covariance (ANCOVA) was performed to explore the potential effects of TD diagnosis, genotype, and their interaction on cognitive function. Results showed a higher prevalence of TD among male patients (27.3%) and significant differences in certain genotypes of the CNR1 gene in relation to TD and the severity of involuntary movements. Moreover, TD patients exhibited greater impairment in visuospatial/construction compared to those without TD. These findings suggest that CNR1 gene polymorphisms may play a role in the development of TD and influence the severity of TD symptoms and cognitive impairments in patients with schizophrenia.
Pubmed: 37739333   DOI: 10.1016/j.brainres.2023.148579

Brandes F, et al. "Extracellular Vesicles and Endocannabinoid Signaling in Patients with COVID-19.." Cannabis and cannabinoid research, 2023.
In the context of COVID-19, there is controversy surrounding the functional role and regulation of endocannabinoid signaling in this pandemic disorder. Endocannabinoids have been found to have immunomodulatory and anti-inflammatory properties, but it is still unclear how they are transported in the vascular system and across cell membranes. However, recent research suggests that extracellular vesicles (EVs) may serve as ideal transport vehicles for these signaling molecules. Through measuring concentrations of various endocannabinoids and miRNAs in EVs and plasma, researchers observed a potential fine-tuning and adaptation of endocannabinoid effects in recipient cells. Additionally, it was found that these EVs also carry immunologically active molecules that can regulate the expression of mRNA transcripts involved in the modulation of endocannabinoid signaling and metabolism. This highlights the potential role of EVs in intercellular communication and regulating the effects of endocannabinoids in COVID-19.
Pubmed: 37713293   DOI: 10.1089/can.2023.0040