mProX™ Human CELSR2 Stable Cell Line

Product Information

Target Protein

CELSR2

Target Family

Cadherin Family

Target Protein Species

Human

Host Cell Type

L02; CHO-K1; HEK293

Target Classification

GPCR Cell Lines

Target Research Area

Metabolic Research

Related Diseases

Orofaciodigital Syndrome; Tracheoesophageal Fistula

Gene ID

1952

UniProt ID

Q9HCU4

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

CELSR2 is a member of the flamingo subfamily, which is a branch of the cadherin superfamily. It is a cadherin EGF LAG seven-pass G-type receptor. Nonclassical cadherins, a fraction of which does not interact with catenins, make up the flamingo subfamily. Studies on the CELSR2 gene are currently mostly concentrated on the processes of serum cholesterol metabolism, coronary artery disease, and diseases of the nervous system. Additionally, some cancers have been discovered to include CELSR2 functionalities. In comparison to benign epithelial cells, breast cancer cells showed enhanced cytoplasmic staining for CELSR2 and inhibitor of growth 4 (ING4), indicating a potential role for both genes in the pathogenesis of human mammary neoplasia. Methylation of CELSR2 has been demonstrated to be crucial for carcinogenesis and tumor development in prostate cancer. The customized CELSR2 stable cell line can be employed in the signaling pathway researches, as well as other applications.

Protocols

Please visit our protocols page.

Customer Reviews

chat Kevin

The CELSR2 cell line is suitable for our high-throughput drug screening. Feb 18 2023

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chat Robert

Very easy to use for drug screening and fast turnaround too. Oct 22 2022

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FAQ

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Published Data

Fig.1 Loss of CELSR2 repressed hepatic lipid accumulation.

Nile red staining in wild-type and CELSR2 knockdown cells. NAFLD/NASH patients' livers and the livers of db/db mice both express less CELSR2. By reducing the expression of lipid production enzymes, CELSR2 depletion drastically reduced the lipid buildup in hepatocytes.

Ref: Tan, J., et al. CELSR2 deficiency suppresses lipid accumulation in hepatocyte by impairing the UPR and elevating ROS level. The FASEB Journal. 2021, 35(10), e21908.

Pubmed: 34478580

DOI: 10.1096/fj.202100786RR

Research Highlights

Atypical cadherin Celsr2 has been shown to have important roles in cilia structure, neuron migration, and axon navigation during neural development.
Wen, Q., et al. Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human. Brain. 2022, 145(2), 670-683.
Pubmed: 34983065 DOI: 10.1093/brain/awab317

Although CELSR2 is thought to be a receptor engaged in contact-mediated communication, the precise role of this particular member in hepatocellular carcinoma (HCC) has not been established.
Xu, M., et al. Identification of CELSR2 as a novel prognostic biomarker for hepatocellular carcinoma. BMC cancer. 2020, 20(1), 1-15.
Pubmed: 32293343 DOI: 10.1186/s12885-020-06813-5

One of the leading causes of illness and mortality worldwide is cardiovascular disease. Warfarin, an anticoagulant with significant interindividual variability and challenging administration, is required for the treatment of a number of cardiovascular disorders.
Al-Eitan, L. N., et al. Influence of PSRC1, CELSR2, and SORT1 gene polymorphisms on the variability of warfarin dosage and susceptibility to cardiovascular disease. Pharmacogenomics and Personalized Medicine. 2020, 13, 619.
Pubmed: 33235484 DOI: 10.2147/PGPM.S274246