mProX™ Human CELSR1 Stable Cell Line
[CAT#: S01YF-0223-KX5]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
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InquiryProduct Information
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
The Celsr1 gene collaborates with a group of conserved "core" planar cell polarity (PCP) genes and proteins, such as Vangl2 or Fzd3 and 6, to regulate polarity in the plane of the epithelium. The adherens junctions of epithelial cells are normally where this atypical cadherin is present. Mice with Celsr1 mutations display issues with neural tube closure, cilia polarity, inner ear hair cells, and cell migration and rearrangement. Craniorachischisis, the most severe form of neural tube closure issues in humans, is associated with CELSR1 mutations. Although Celsr1 is highly and consistently expressed throughout the germinal zones of the growing forebrain, nothing is known about its function after the neural tube closes. The customized CELSR1 stable cell line can be employed in the signaling pathway researches, as well as the screening of potential therapeutic candidates.
Protocols
Please visit our protocols page.
Customer Reviews
Taisei
I customized a CELSR1 knockout cell line and it was verified that the product meets my requirement.
Mar 05 2022
Verified Customer
Nick
This cell line is very suitable for studying the CELSR1 signaling pathway.
Jan 11 2023
Verified Customer
FAQ
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