mProX™ Human CCR10 Stable Cell Line
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- GPCR Cell Lines
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InquiryBased on this stable cell line, we also provide cell-based in vitro assays to evaluate the effects of your compounds or antibodies.
| Sub Cat | Product Name | Target Protein Species | Host Cell Type | Assay Types | Inquiry | Datasheet |
|---|---|---|---|---|---|---|
| S01YF-1122-KX289 | Magic™ Mouse CCR10 in Vitro Calcium Flux Assay | Mouse | CHO-K1-Gqi5 | Calcium Flux Assay |
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Published Data
Fig.1 CCR10 played a pivotal role in facilitating breast cancer cell invasion and migration induced by CCL27.
Upon the attenuation of CCR10 expression via siRNAs, cellular stimulation ensued with 100 ng/ml CCL27, followed by the undertaking of assessments for both invasion and migration. Statistical significance was indicated as * p < 0.05.
Ref: Lin, Hao-yu, et al. "CCR10 activation stimulates the invasion and migration of breast cancer cells through the ERK1/2/MMP-7 signaling pathway." International Immunopharmacology 51 (2017): 124-130.
Pubmed: 28830025
DOI: 10.1016/j.intimp.2017.07.018
Research Highlights
Chu YT, et al. "Interplay of Chemokines Receptors, Toll-like Receptors, and Host Immunological ." Biomedicines, 2023.
The study identified multiple chemokine receptors, including CCR5, CCR1, CCR4, CCR3, CCR10, CCR6, CXCR3, and CCR8, involved in T helper (TH) cell responses. CCR5 was found to be associated with TH1 responses, while CCR1 was linked to TH1-like responses. CCR4 and CCR3 played a role in TH2 and TH9 responses in basophils and eosinophils, respectively. CCR10 was found to be involved in TH22 responses, CCR6 in TH17 responses, CXCR3 in THalphabeta responses, and CCR8 in regulatory T cell (Treg) responses. These discoveries provide potential biomarkers for immune cells and a better understanding of the host's immune system. Additionally, comprehending the chemokine and Toll-like receptor system is crucial for understanding the innate and adaptive immune responses.
Pubmed:
37760825
DOI:
10.3390/biomedicines11092384
Seth P, Dubey S. "IL-22 as a target for therapeutic intervention: Current knowledge on its role in ." Cytokine, 2023.
IL-22 is a vital cytokine involved in protective responses against infections and tissue repair. Abnormal levels of IL-22 have been linked to the development of various diseases, including cancers and autoimmune disorders. As a member of the IFN-IL-10 cytokine family, IL-22 is primarily released by activated Th1 cells (Th22) and can also be produced by other immune cells like innate lymphocytes and T cells. Unlike other Th cell subsets, Th22 cells exclusively secrete IL-22 and express the aryl hydrocarbon receptor. They also express chemokine receptors that aid in enhancing epithelial barrier immunity and stimulating the production of antimicrobial peptides from intestinal cells. The function of IL-22 is regulated by IL-22 binding protein, which competes with its cell surface receptor. Additionally, the role of Th22 cells in disease progression is influenced by the infected tissue and type of illness. This review aims to discuss the important aspects of IL-22 biology, compare it with IFN-gamma, and highlight its potential as a target for immune therapy in various diseases.
Pubmed:
37441942
DOI:
10.1016/j.cyto.2023.156293
