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    Family stable cell lines Cholecystokinin Family Stable Cell Lines; Innovative Tools, Membrane Protein Drug Discovery.

    mProX™ Human CCKBR Stable Cell Line

    [CAT#: S01YF-0923-PY56]
    Product Category:
    Membrane Protein Stable Cell Lines
    Subcategory:
    GPCR Cell Lines

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    Product Information

    Target Protein
    CCKBR
    Target Family
    Cholecystokinin Family
    Target Protein Species
    Human
    Host Cell Type
    MCF-7;T47D;CHO-K1;HEK293
    Target Classification
    GPCR Cell Lines
    Target Research Area
    CNS Research
    Related Diseases
    Panic Disorder;Anxiety
    Gene ID
    Human: 887
    UniProt ID
    Human: P32239

    Product Properties

    Biosafety Level
    Level 1
    Activity
    Yes
    Quantity
    10⁶ cells per vial
    Applications
    Cholecystokinin B receptor (CCKBR) is primarily known for its role in the gastrointestinal system, where it mediates the effects of the hormone gastrin. This receptor plays a pivotal role in stimulating acid secretion in the stomach. Beyond its gastrointestinal functions, recent research has unveiled the potential of CCKBR in regulating blood pressure, particularly in the context of salt-sensitive hypertension. Moreover, the therapeutic potential of targeting CCKBR in cancer has been explored, with studies suggesting that modulating its activity can impact tumor growth and progression.

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    Please visit our protocols page.

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    FAQ

    chat Gary (Verified Customer)

    How does CCKBR influence salt-sensitive hypertension? Mar 12 2022

    chat Patrick Liam (Creative Biolabs Scientific Support)

    Intestinal CCKBR plays a crucial role in regulating blood pressure. It has been found that the gastrin/CCKBR system in the intestine can ameliorate salt-sensitive hypertension by inhibiting the activity of the Na+/H+ exchanger 3 through a PKC-mediated pathway. Mar 12 2022

    chat Shirley (Verified Customer)

    What is the therapeutic potential of CCKBR in tumors? Jan 27 2020

    chat Patrick Liam (Creative Biolabs Scientific Support)

    CCKBR has been identified as a potential target to improve the therapeutic efficacy of radiolabeled minigastrin analogues in CCKBR-positive cancers. This suggests that modulating CCKBR can enhance the treatment outcomes for certain types of cancers. Jan 27 2020

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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR CLINICAL PROCEDURES" For licensing inquiries, please contact
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