mProX™ Human CACNA1I Stable Cell Line
[CAT#: S01YF-1123-KX14]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Target Protein
CACNA1I
Target Family
Voltage Gated Calcium Channel
Target Protein Species
Human
Host Cell Type
Neuro2A; CHO-K1; HEK293
Target Classification
Ion Channel Cell Lines
Target Research Area
CNS Research
Related Diseases
Autosomal Dominant Non-Syndromic Intellectual Disability; Epilepsy
Gene ID
UniProt ID
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
One of the three main CaV3 voltage-gated calcium (CaV) channels that contributes to low threshold T-type currents, CACNA1I encodes the pore-forming hCaV3.3 α1 subunit. CaV3 channels feature slower closure speeds, quick inactivation, and low voltage-activation thresholds when compared to CaV channels. The CaV3.3 channels, one of the three members of the CaV3 family, have the greatest depolarized activation thresholds; they also open, inactivate, and close slowly. A small fraction of neurons, particularly GABAergic neurons in the thalamic reticular nucleus (TRN), have CaV3.3 channels, which promote oscillatory activity necessary for the production of the sleep spindle. CaV3.3 channels have a key role in mediating rebound bursts during brief membrane hyperpolarizations in TRN neurons, where they are largely inactive at resting membrane potentials. The customized CACNA1I stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Jason
The CACNA1I cell line is suitable for our high-throughput drug screening.
Sep 24 2021
Verified Customer
Robert
Very easy to use for drug screening and fast turnaround too.
Oct 30 2021
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
