mProX™ Human CACNA1H Stable Cell Line
[CAT#: S01YF-1123-KX13]
- Product Category:
- Membrane Protein Stable Cell Lines
- Subcategory:
- Ion Channel Cell Lines
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Made to Order Inquiry
InquiryProduct Information
Product Properties
Biosafety Level
Level 1
Activity
Yes
Quantity
10⁶ cells per vial
Applications
A gene associated with epilepsy susceptibility has been identified as CACNA1H. Patients with CAE, one of the most prevalent forms of IGEs, were the first to have mutations in this gene found. As a result of CACNA1H's alternative splicing at 12-14 locations, several isoforms with various biophysical, modulatory, and pharmacological characteristics can be produced. There is strong evidence to suggest that the context of the splice variant affects how mutations, such as the CaV3.2 mutation (gcm) in the genetic absence epilepsy rats from Strasbourg (GAERS), alter channel characteristics. The gcm mutation, which results in an R1584P substitution in exon 24 of CACNA1H, is a G to C single nucleotide change. This exon encodes a section of the linker of domain III-IV in the CaV3.2 channel. The customized CACNA1H stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.
Protocols
Please visit our protocols page.
Customer Reviews
Deborah
I customized a CACNA1H overexpression cell line and it was verified that the product meets my requirement.
Jul 10 2023
Verified Customer
Laura
This cell line is very suitable for studying the CACNA1H signaling pathway.
Jan 27 2023
Verified Customer
FAQ
Any questions about our products? Please visit our frequently asked questions page.
