mProX™ Human CACNA1C Stable Cell Line

Product Information

Target Protein

CACNA1C

Target Family

Voltage Gated Calcium Channel

Target Protein Species

Human

Host Cell Type

Neuro2A; CHO-K1; HEK293

Target Classification

Ion Channel Cell Lines

Target Research Area

CNS Research

Related Diseases

Timothy Syndrome; Long Qt Syndrome

Gene ID

775

UniProt ID

Q13936

Product Properties

Biosafety Level

Level 1

Activity

Yes

Quantity

10⁶ cells per vial

Applications

Making one of the calcium channels is controlled by the CACNA1C gene. CaV1.2 is the name of the calcium channel that the CACNA1C gene produces. Although these channels can be found in many different cell types, it appears that cardiomyocytes and brain neurons in particular rely on them for proper operation. CaV1.2 channels in the heart regulate the influx of calcium ions into cardiomyocytes at particular intervals during each heartbeat. To keep the heart functioning normally, the length of time the channels are open and closed is controlled. CaV1.2 channels are believed to play a role in memory, the fear response, and the quick transmission of nerve signals in the brain. The customized CACNA1C stable cell line can be used in antibody discovery and development, potential drug candidate screening and signaling pathway researches.

Protocols

Please visit our protocols page.

Customer Reviews

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FAQ

chat Sharon (Verified Customer)

Is CACNA1C involved in cardiac conduction disorders? Feb 09 2022

chat Sherry Smith (Creative Biolabs Scientific Support)

Yes, polymorphisms of the CACNA1C gene have been associated with primary cardiac conduction disorders. Feb 09 2022

chat Ronald (Verified Customer)

How does CACNA1C influence memory related to affective information? Sep 26 2020

chat Sherry Smith (Creative Biolabs Scientific Support)

CACNA1C has been studied for its role in the production of false memories for affective information. Sep 26 2020

Published Data

Fig.1 CCAT is Translated from an Independent Transcript Driven by an Exonic Promoter.

mRNA isolated from Neuro2A cells producing Cav1.2-Gal4 channel constructs with or without the CMV promoter was subjected to Northern blot analysis. The mRNA from untransfected cells is in the first lane.

Ref: Gomez-Ospina, Natalia, et al. "A promoter in the coding region of the calcium channel gene CACNA1C generates the transcription factor CCAT." PloS one 8.4 (2013): e60526.

Pubmed: 23613729

DOI: 10.1371/journal.pone.0060526

Research Highlights

Numerous large-scale genome-wide association studies have repeatedly demonstrated that the risk of psychiatric diseases is increased by genetic variation in CACNA1C. The voltage-gated calcium channel Cav1.2 subunit, which is encoded by CACNA1C, has been functionally linked to a wide range of neuropsychiatric disorders.
Moon, Anna L., et al. "CACNA1C: association with psychiatric disorders, behavior, and neurogenesis." Schizophrenia bulletin 44.5 (2018): 958-965.
Pubmed: 29982775 DOI: 10.1093/schbul/sby096

Numerous mental illnesses have been linked to calcium channel subunits, such as CACNA1C. In particular, genome wide association studies (GWAS) have consistently found a high correlation between schizophrenia and bipolar disorder and the single nucleotide polymorphism (SNP) rs1006737 in CACNA1C's intron 3.
Eckart, Nicole, et al. "Functional characterization of schizophrenia-associated variation in CACNA1C." PLoS One 11.6 (2016): e0157086.
Pubmed: 27276213 DOI: 10.1371/journal.pone.0157086